Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines.
Jean D. Sipe,Merrill D. Benson,Joel N. Buxbaum,Shu-ichi Ikeda,Giampaolo Merlini,Maria João Saraiva,Per Westermark +6 more
TLDR
Two proteins which were previously characterized as intracellular inclusions, tau and α-synuclein, are now recognized to form extracellular deposits upon cell death and thus have been included in Table 1 as ATau and AαSyn.Abstract:
The Nomenclature Committee of the International Society of Amyloidosis (ISA) met during the XVth Symposium of the Society, 3 July–7 July 2016, Uppsala, Sweden, to assess and formulate recommendatio...read more
Citations
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Journal ArticleDOI
A new era for understanding amyloid structures and disease.
TL;DR: The first near-atomic-resolution structures of amyloid fibrils formed in vitro, seeded from plaque material and analysed directly ex vivo are now available and reveal cross-β structures that are far more intricate than anticipated.
Journal ArticleDOI
Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee
Merrill D. Benson,Joel N. Buxbaum,David Eisenberg,Giampaolo Merlini,Maria João Saraiva,Yoshiki Sekijima,Jean D. Sipe,Per Westermark +7 more
TL;DR: The nomenclature committee of the International Society of Amyloidosis (ISA) meets every second year to discuss and formulate recommendations as discussed by the authors, and the conclusions from the discussion at the XVI International Symposium on Amyloids in Kumamoto, Japan, 25-29 March 2018 and afterwards are summarized in this Nomenclatures Article.
Journal ArticleDOI
Systemic immunoglobulin light chain amyloidosis.
Giampaolo Merlini,Angela Dispenzieri,Vaishali Sanchorawala,Stefan Schönland,Giovanni Palladini,Philip N. Hawkins,Morie A. Gertz +6 more
TL;DR: Passive immunotherapies targeting clonal plasma cells and directly accelerating removal of amyloid deposits promise to further improve the overall outlook of this increasingly treatable disease.
Amyloid nomenclature 2018: recommendations by the International Society of Amyloidosis (ISA) nomenclature committee
Merrill D. Benson,Joel N. Buxbaum,David Eisenberg,Giampaolo Merlini,Maria João Saraiva,Yoshiki Sekijima,Jean D. Sipe,Per Westermark +7 more
TL;DR: From having recommended the use of the designation “amyloid fibril” for in vivo material only, ISA’s nomenclature committee now accepts its use more broadly following the international scientific literature.
Journal ArticleDOI
ASNC/AHA/ASE/EANM/HFSA/ISA/SCMR/SNMMI expert consensus recommendations for multimodality imaging in cardiac amyloidosis: Part 1 of 2—evidence base and standardized methods of imaging
Sharmila Dorbala,Yukio Ando,Sabahat Bokhari,Angela Dispenzieri,Rodney H. Falk,Victor A. Ferrari,Marianna Fontana,Olivier Gheysens,Julian D. Gillmore,Andor W. J. M. Glaudemans,Mazen Hanna,Bouke P. C. Hazenberg,Arnt V. Kristen,Raymond Y. Kwong,Mathew S. Maurer,Giampaolo Merlini,Edward J. Miller,James C. Moon,Venkatesh L. Murthy,Candida Cristina Quarta,Claudio Rapezzi,Frederick L. Ruberg,Sanjiv J. Shah,Riemer H. J. A. Slart,Hein J. Verberne,Jamieson M. Bourque +25 more
TL;DR: This document was approved for publication by the governing body of the American Society of Nuclear Cardiology and was endorsed by the American College of Cardiology, the American Heart Association, and the Heart Failure Society of America.
References
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Nonbiopsy Diagnosis of Cardiac Transthyretin Amyloidosis.
Julian D. Gillmore,Mathew S. Maurer,Rodney H. Falk,Giampaolo Merlini,Thibaud Damy,Angela Dispenzieri,Ashutosh D. Wechalekar,John L. Berk,John L. Berk,Candida Cristina Quarta,Martha Grogan,Helen J. Lachmann,Sabahat Bokhari,Adam Castano,Sharmila Dorbala,Geoff B. Johnson,Andor W. J. M. Glaudemans,Tamer Rezk,Marianna Fontana,Giovanni Palladini,Paolo Milani,P.L Guidalotti,Katarina Flatman,Thirusha Lane,Frederick W. Vonberg,Carol J. Whelan,James C. Moon,Frederick L. Ruberg,Frederick L. Ruberg,Edward J. Miller,David F. Hutt,Bouke P. C. Hazenberg,Claudio Rapezzi,Philip N. Hawkins +33 more
TL;DR: Bone scintigraphy enables the diagnosis of cardiac ATTR amyloidosis to be made reliably without the need for histology in patients who do not have a monoclonal gammopathy, and proposes noninvasive diagnostic criteria that are applicable to the majority of patients with this disease.
Journal ArticleDOI
HGVS Recommendations for the Description of Sequence Variants: 2016 Update
Johan T. den Dunnen,Raymond Dalgleish,Donna Maglott,Reece K. Hart,Marc S. Greenblatt,Jean McGowan-Jordan,Anne-Françoise Roux,Timothy D. Smith,Stylianos E. Antonarakis,Peter E.M. Taschner +9 more
TL;DR: The current recommendations, HGVS version 15.11, are presented, and briefly summarize the changes that were made since the 2000 publication, with most focus on removing inconsistencies and tightening definitions allowing automatic data processing.
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Fibril in senile systemic amyloidosis is derived from normal transthyretin.
TL;DR: It is shown that the TTR molecule in SSA, on the other hand, has a normal primary structure, and factors other than the primary structure of TTR must therefore be important in the pathogenesis of T TR-derived amyloid.
Journal ArticleDOI
Semen-Derived Amyloid Fibrils Drastically Enhance HIV Infection
Jan Münch,Elke Rücker,Ludger Ständker,Knut Adermann,Christine Goffinet,Michael Schindler,Steffen Wildum,Raghavan Chinnadurai,Devi Rajan,Anke Specht,Guillermo Giménez-Gallego,Pedro Cuevas Sánchez,Douglas M. Fowler,Atanas V. Koulov,Jeffery W. Kelly,Walther Mothes,Jean-Charles Grivel,Leonid Margolis,Oliver T. Keppler,Wolf-Georg Forssmann,Frank Kirchhoff +20 more
TL;DR: It is shown that naturally occurring fragments of the abundant semen marker prostatic acidic phosphatase form amyloid fibrils, termed Semen-derived Enhancer of Virus Infection (SEVI), capture HIV virions and promote their attachment to target cells, thereby enhancing the infectious virus titer by several orders of magnitude.
Journal ArticleDOI
Nomenclature 2014: Amyloid fibril proteins and clinical classification of the amyloidosis
Jean D. Sipe,Merrill D. Benson,Joel N. Buxbaum,Shu-ichi Ikeda,Giampaolo Merlini,Maria João Saraiva,Per Westermark +6 more
TL;DR: The Nomenclature Committee of the International Society of Amyloidosis met during the XIVth Symposium of the Society, April 27–May 1, 2014, Indianapolis, IN, to assess and formulate recommend new names for amyloid beta-cell types.
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