Journal ArticleDOI
An Overview of Novel Adjuvants Designed for Improving Vaccine Efficacy
Srinivasa Reddy Bonam,Srinivasa Reddy Bonam,Charalambos D. Partidos,Sampath Kumar M. Halmuthur,Sylviane Muller,Sylviane Muller +5 more
TLDR
This review focuses on several promising adjuvants that are currently at various stages of development or clinical evaluation, and summarizes recent work conducted in various laboratories to develop novel lipid-containing adjuvant.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2017-09-01. It has received 181 citations till now. The article focuses on the topics: Vaccine efficacy.read more
Citations
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Combination Cancer Therapy with Immune Checkpoint Blockade: Mechanisms and Strategies.
Shetal A. Patel,Andy J. Minn +1 more
TL;DR: A framework for rationally designing combination therapy strategies based on enhancing major discriminatory functions of the immune system that are corrupted by cancer-namely, antigenicity, adjuvanticity, and homeostatic feedback inhibition is discussed.
Journal ArticleDOI
Optimizing the utilization of aluminum adjuvants in vaccines: you might just get what you want.
TL;DR: The properties of aluminum adjuvants are reviewed and those elements that are critical to optimize vaccine performance are highlighted, which will ultimately contribute to the successful development of newer, more effective and safer vaccines.
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Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines
Thai Thanh Hoang Thi,Estelle J.A. Suys,Jung Seok Lee,Dai Hai Nguyen,Ki Dong Park,Nghia P. Truong +5 more
TL;DR: A review of lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines, is presented in this article, focusing on the innovations that have obtained regulatory approval or that are in clinical trials.
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Next-generation influenza vaccines: opportunities and challenges
TL;DR: Approaches to improve vaccine efficacy which harness new insights from influenza antigen structure and human immunity are discussed, highlighting major targets, vaccines in development and ongoing challenges.
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Liposomes used as a vaccine adjuvant-delivery system: From basics to clinical immunization.
Ning Wang,Minnan Chen,Ting Wang +2 more
TL;DR: This article describes in depth some critical issues relevant to the development of liposomes as a VADS, including principles underlying immunization, physicochemical properties of lipOSomes as the immunity-influencing factors, functional material modification to enhance immunostimulatory functions, the state-of-the-art liposome VADSs, as well as the marketed vaccines based on a liposom VADS.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
Osamu Takeuchi,Shintaro Sato,Takao Horiuchi,Katsuaki Hoshino,Kiyoshi Takeda,Zhongyun Dong,Robert L. Modlin,Shizuo Akira +7 more
TL;DR: This paper showed that TLR1-deficient mice showed impaired proinflammatory cytokine production in response to 19-kDa lipoprotein and a synthetic triacylated lipopeptide.
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Mucosal immunity and vaccines
Jan Holmgren,Cecil Czerkinsky +1 more
TL;DR: The properties of the mucosal immune system are reviewed and advances in the development of mucosal vaccines for protection against infections and for treatment of various inflammatory disorders are discussed.
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Discrimination of bacterial lipoproteins by Toll-like receptor 6
Osamu Takeuchi,Taro Kawai,Peter F. Mühlradt,Michael Morr,Justin D. Radolf,Arturo Zychlinsky,Kiyoshi Takeda,Shizuo Akira +7 more
TL;DR: Results show that TLR6 recognizes MALP-2 cooperatively with TLR2, and appears to discriminate between the N-terminal lipoylated structures of MALp-2 and lipopeptides derived from other bacteria.
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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Mi Sun Jin,Sung-Eun Kim,Jin Young Heo,Mi Eun Lee,Ho Min Kim,Sang-Gi Paik,Hayyoung Lee,Jie-Oh Lee +7 more
TL;DR: It is proposed that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.