Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Structure, fonction biologique et utilité clinique des angiopoiétines 1 et 2 dans l’exploration de la dysfonction endothéliale
Youssef Bennis,Saïd Kamel +1 more
TL;DR: In this paper, the authors present the structure and different activites biologiques au niveau vasculaire des angiopoietines and, d'autre part, de presenter les differentes etudes cliniques et biologique dans lesquelles les concentrations circulantes des angioietines se sont averees etre de bons marqueurs biologiciques de la dysfonction endotheliale.
Journal ArticleDOI
Placental Growth Factor Regulates Angiopoietin-1 and Tie-2 Genes via VEGFR1 Signaling in Human Retinal Endothelial Cell-Pericyte Cocultures and iPSC-Derived Vascular Organoids
Journal ArticleDOI
Circulating angiogenic factors in diabetes patients in a tertiary hospital in Ghana
Kwame Yeboah,Eric Kyei-Baafour,Daniel A. Antwi,Henry Asare-Anane,Ben Gyan,Albert G.B. Amoah,Albert G.B. Amoah +6 more
TL;DR: Having diabetes and hypertension increased the levels of Ang-1 and Ang-2, and low eGFR status was associated with increased levels of angiogenic growth factors after adjustment for other risk factors.
Understanding regulatory pathways of neovascularization in
Melanie Rodrigues,Robert C. Rennert,Arnetha J. Whitmore,Dominik Duscher,Michael Januszyk,Michael S. Hu,Alexander J. Whittam,Christopher R. Davis,Geoffrey C +8 more
TL;DR: The mechanisms by which hyperglycemia disrupts chemokine expression and function, including the critical hypoxia inducible factor-1 axis are explored, with particular emphasis on the therapeutic potential of strategies addressing these pathways.
Is Angiopiotin-2 Useful in Evaluation of Pediatric Patients with Sepsis?
TL;DR: In this article , the authors evaluated the utility of angiopoietin-2 in diagnosis and prognosis of pediatric sepsis in two groups; patients group and control group, including 70 children admitted to the Pediatric Intensive Care Unit with diagnosis of sepis.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more