Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
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Sequential dysregulated plasma levels of angiopoietins (ANG-2 and ratios of ANG-2/ANG-1) are associated with malaria severity and mortality among hospital admitted cases in South Bastar Region of Chhattisgarh, Central India.
TL;DR: In this paper, a study was carried out in Maharani hospital and associated Medical College, Jagdalpur, CG, Central India from 2010 to 2014, where angiopoietins (ANG-1 and ANG-2) were measured by ELISA in all the samples at the time of admission and 48 hours of treatment.
Journal ArticleDOI
Function and Therapeutic Potential of Mesenchymal Stem Cells and Their Acellular Derivatives on Non-Healing Chronic Skin Ulcers
Victor Alfonso Solarte,Silvia Becerra-Bayona,Lissette Sanchez-Aranguren,Claudia Sossa,Alvaro Meana,Jesus Merayo-Lloves,Martha L. Arango-Rodríguez +6 more
TL;DR: The characteristics of MSCs as well as their regenerative properties and their action mechanisms on wound healing are discussed and the perspectives of M SCs and their acellular derivatives in clinical chronic skin ulcer therapy are explored.
Posted ContentDOI
Embryonic Protein NODAL Regulates the Breast Tumour Microenvironment by Reprogramming Cancer-Derived Secretomes
Dylan Dieters-Castator,Paola M. Dantonio,Matt Piaseczny,Guihua Zhang,Jiahui Liu,Miljan Kuljanin,Stephen E. Sherman,Michael Jewer,Katherine Quesnel,Eun Young Kang,Martin Koebel,Gabrielle M. Siegers,Andrew Leask,David A. Hess,Gilles A. Lajoie,Lynne-Marie Postovit +15 more
TL;DR: It is shown that NODAL expression correlates with the presence of activated fibroblasts in human triple negative breast cancers and that it directly induces CAF phenotypes and reprograms cancer cell secretomes by simultaneously altering levels of chemokines, cytokines, and growth factors, leading to alterations in MSC chemotaxis.
Journal ArticleDOI
Secretive derived from hypoxia preconditioned mesenchymal stem cells promote cartilage regeneration and mitigate joint inflammation via extracellular vesicles.
Yanmeng Yang,Yingnan Wu,Dahou Yang,Shu Hui Neo,Nurul Dinah Kadir,J. Tan,Vinitha Denslin,Eng Hin Lee,Zheng Yang +8 more
TL;DR: In this paper , the paracrine effects of secretome derived from mesenchymal stem cells (MSCs) preconditioned in normoxia and hypoxia was compared through both in vitro functional assays and an in vivo rat osteochondral defect model.
Journal ArticleDOI
Successes and failures of angiogenesis blockade in gastric and gastro-esophageal junction adenocarcinoma
Massimiliano Salati,Francesco Caputo,Alessandro Lamberti Bocconi,Sara Cerri,Cinzia Baldessari,Federico Piacentini,Massimo Dominici,Fabio Gelsomino +7 more
TL;DR: The existing literature on the biological rationale and clinical development of antiangiogenic agents in GEA is critically reviewed, discussing major achievements, limitations and future developments, aiming at fully realizing the potential of this therapeutic approach.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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