Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
TL;DR: Recent discoveries of new mechanisms underlying angiogenesis are examined, successes and challenges of current antiangiogenic therapy are discussed, and emerging antiangIogenic paradigms are highlighted.
Journal ArticleDOI
Diabetes and Wound Angiogenesis.
TL;DR: This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis and considers therapeutics that may offer promise to better wound healing outcomes.
Journal ArticleDOI
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Lei Zhong,Y. Li,Liang Xiong,Wen-Jing Wang,Ming Wu,Ting Yuan,Wei Yang,Chenyu Tian,Zhuang Miao,Tianqi Wang,Shengyong Yang +10 more
TL;DR: A comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification is conducted, which presents all the approved drugs as well as important drug candidates in clinical trials for each target, and discusses the current challenges.
Journal ArticleDOI
Macro- and microvascular endothelial dysfunction in diabetes
Yi Shi,Paul M. Vanhoutte +1 more
TL;DR: This reviews pays special attention to microRNAs and their modulatory role in diabetes‐induced vascular dysfunction and some therapeutic strategies for preventing and restoring diabetic endothelial dysfunction are highlighted.
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FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)
TL;DR: The dual inhibition of FGF and CSF1 or VEGF signaling is expected to enhance the antitumor effects through the targeting of immune evasion and angiogenesis in the tumor microenvironment.
References
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Journal ArticleDOI
Angiopoietin-3, a novel member of the angiopoietin family.
Motoi Nishimura,Takashi Miki,Rei Yashima,Norihide Yokoi,Hideki Yano,Yasufumi Sato,Susumu Seino +6 more
TL;DR: A cDNA clone encoding angiopoietin-3 protein (Ang3) was identified in this paper, which was cloned from a human aorta cDNA library.
Journal ArticleDOI
Angiopoietin-2, an angiogenic regulator, promotes initial growth and survival of breast cancer metastases to the lung through the integrin-linked kinase (ILK)-AKT-B cell lymphoma 2 (Bcl-2) pathway.
TL;DR: The data underscore the importance that up-regulated Ang2 not only stimulates breast cancer growth and metastasis at late stages of the process, but is also critical at the initiating stages of metastases onset, thereby suggesting Ang2 as a promising therapeutic target for treating patients with metastatic breast cancer.
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A decreased ratio between serum levels of the antagonistic angiopoietins 1 and 2 indicates tumour progression of malignant melanoma
Masyar Gardizi,Christine Kurschat,Anna Riese,Moritz Hahn,Thomas Krieg,Cornelia Mauch,Peter Kurschat +6 more
TL;DR: The ratio between both angiopoietins is significantly altered in late stage melanoma patients, shifting the balance to favour angiogenesis.
Journal ArticleDOI
Construction of a ganciclovir-sensitive lentiviral vector to assess the influence of angiopoietin-3 and soluble Tie2 on glioma growth
TL;DR: This study helps to understand the importance of the Tie2 signaling pathway in glioma development and the role of Angpt3, but suggests that neither this molecule nor sTie2 are effective agents against malignant gliomas.
Journal ArticleDOI
Angiopoietin-3 overexpression in tobacco smoke-induced mouse lung tumors and its relation to vitamin E intervention.
Suolian Zhang,Zhaoli Chen,Jie Yang,Guofan Zhao,Min Jin,Zhiqiang Shen,Jingfeng Wang,Zhigang Qiu,Xin-Wei Wang,Jun-Wen Li +9 more
TL;DR: It is indicated that smoking could upregulate the expression of Ang-3, which may play an important role in the carcinogenesis and development of smoke-induced lung cancer, and could also be a target in lung cancer treatment.
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