Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Journal ArticleDOI
Angiopoietin 2 in type 2 diabetes mellitus patients and those with complications: an observational comparative study
TL;DR: It was found that angiopoietin 2 is also a good biomarker for diabetes as HbA1c and helps in detection of complications earlier and thus may help in reducing morbidity as well as mortality.
Journal ArticleDOI
Sprouting Angiogenesis in Human Pituitary Adenomas
Jie Zhou,Yaomin Hu,Wende Zhu,Chuansheng Nie,Wenxiu Zhao,Alexander T. Faje,Kathryn E. Labelle,Brooke Swearingen,Hang Lee,E. T. Hedley-Whyte,Xun Zhang,Pamela S. Jones,Karen K. Miller,Anne Klibanski,Yunli Zhou,Roy J. Soberman +15 more
TL;DR: Human pituitsary tumors are characterized by more active angiogenesis than normal pituitary gland tissue in a manner consistent with sprouting angiogenic, and VEGFR inhibitors inhibited angiogenicity induced by human pituitaries and prolonged survival of RbΔ19 mice.
Journal ArticleDOI
Two-Stage Gene Therapy (VEGF, HGF and ANG1 Plasmids) as Adjunctive Therapy in the Treatment of Critical Lower Limb Ischemia in Diabetic Foot Syndrome
Piotr Barć,Maciej Antkiewicz,Katarzyna Frączkowska-Sioma,Diana Kupczyńska,Paweł Lubieniecki,Wojciech Witkiewicz,Malgorzata Malodobra-Mazur,Dagmara Baczyńska,Dariusz Janczak,Jan Skóra +9 more
TL;DR: The effectiveness of gene therapy with the growth factors described above in patients with CLI in the course of complicated DM was shown to be effective with minimal side effects.
Dissertation
Evènements moléculaires spécifiques au cours des adénocarcinomes pulmonaires lépidiques humains et animaux
TL;DR: Premierment, notre etude a porte sur l'Analyse en parallele des mecanismes moleculaires specifiques des adenocarcinomes lepidiques predominants par l'analyse des profils d'expression des genes impliques dans les voies de signalisation BMI1, NOTCH, Hedgehog et WNT.
Journal ArticleDOI
Melatonin and endothelial cell-loaded alginate-fibrin hydrogel promoted angiogenesis in rat cryopreserved/thawed ovaries transplanted to the heterotopic sites
Melika Izadpanah,Azizeh Rahmani Del Bakhshayesh,Zahra Bahroudi,Abbas Majdi Seghinsara,Rahim Beheshti,Mahdi Mahdipour,Mahsa Rezaei Zarnaghi,Parisa Hassanpour,Narges Mardi,Reza Rahbarghazi,Ali Abedelahi +10 more
TL;DR: In this paper , the angiogenic potential of alginate (Alg) + fibrin (Fib) hydrogel enriched with melatonin (Mel) and CD144+ endothelial cells (ECs) was assessed on encapsulated cryopreserved/thawed ovaries following transplantation to heterotopic sites in rats.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more