Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Journal ArticleDOI
Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta
Ricardo Ataíde,Ricardo Ataíde,Oscar Murillo,Jamille Gregório Dombrowski,Rodrigo Medeiros de Souza,Rodrigo Medeiros de Souza,Flávia Afonso Lima,Giselle Fernandes Maciel de Castro Lima,Angelica D. Hristov,Suiane da Costa Negreiros do Valle,Silvia Maria Di Santi,Sabrina Epiphanio,Claudio Romero Farias Marinho +12 more
TL;DR: In this study, MiP was not associated with severe outcomes, but an increased ratio of peripheral Tie-2:Ang-1 was associated with the occurrence of MiP and Malaria in pregnancy is an effect modifier of the association between Ang-1 and placental barrier thickness.
Journal ArticleDOI
Synthesis of Human Neutrophil Extracellular Traps Contributes to Angiopoietin-Mediated In Vitro Proinflammatory and Proangiogenic Activities.
Simon S. Lavoie,Simon S. Lavoie,Elizabeth Dumas,Elizabeth Dumas,Branka Vulesevic,Branka Vulesevic,Paul-Eduard Neagoe,Michel White,Michel White,Martin G. Sirois,Martin G. Sirois +10 more
TL;DR: The capacity of Ang1 and Ang2 to promote the release of NETs and that these NETs contribute to angiopoietin-mediated in vitro proinflammatory and proangiogenic activities are reported.
Journal ArticleDOI
Imbalanced serum levels of Ang1, Ang2 and VEGF in systemic sclerosis: Integrated effects on microvascular reactivity
TL;DR: It is found that serum levels of Ang1, Ang2 and VEGF are differentially expressed in SSc and altered Ang1/Ang2 profile might underlay the aberrant angiogenesis in S sc despite increase in V EGF.
Journal ArticleDOI
Three-Dimensional Vascularized Lung Cancer-on-a-Chip with Lung Extracellular Matrix Hydrogels for In Vitro Screening.
TL;DR: In this paper, a 3D vascularized lung cancer-on-a-chip (VLCC) was developed using decellularized lung extracellular matrix (ldECM) and pro-angiogenic factors.
Journal ArticleDOI
Vascularisation for cardiac tissue engineering: the extracellular matrix
TL;DR: The current literature supports the notion that cardiac tissue engineering is a realistic option for future treatment of paediatric and adult patients with cardiac disease.
References
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Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Isolation of putative progenitor endothelial cells for angiogenesis.
Takayuki Asahara,Toyoaki Murohara,Alison Sullivan,Marcy Silver,Rien van der Zee,Tong Li,Bernhard Witzenbichler,Gina C. Schatteman,Jeffrey M. Isner +8 more
TL;DR: It is suggested that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarianAngiogenesis.
Journal ArticleDOI
Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more
TL;DR: Preclinical and clinical studies have shown new molecular targets and principles, which may provide avenues for improving the therapeutic benefit from anti-angiogenic strategies.
Journal ArticleDOI
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre Peter C,Chitra Suri,Pamela F. Jones,Sona Bartunkova,Stanley J. Wiegand,Czeslaw Radziejewski,Debra L Compton,Joyce Mcclain,Aldrich Thomas H,Nick Papadopoulos,Thomas J. Daly,Samuel Davis,Thomas N. Sato,George D. Yancopoulos +13 more
TL;DR: The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
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Molecular mechanisms and clinical applications of angiogenesis
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