Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
TL;DR: Recent discoveries of new mechanisms underlying angiogenesis are examined, successes and challenges of current antiangiogenic therapy are discussed, and emerging antiangIogenic paradigms are highlighted.
Journal ArticleDOI
Diabetes and Wound Angiogenesis.
TL;DR: This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis and considers therapeutics that may offer promise to better wound healing outcomes.
Journal ArticleDOI
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Lei Zhong,Y. Li,Liang Xiong,Wen-Jing Wang,Ming Wu,Ting Yuan,Wei Yang,Chenyu Tian,Zhuang Miao,Tianqi Wang,Shengyong Yang +10 more
TL;DR: A comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification is conducted, which presents all the approved drugs as well as important drug candidates in clinical trials for each target, and discusses the current challenges.
Journal ArticleDOI
Macro- and microvascular endothelial dysfunction in diabetes
Yi Shi,Paul M. Vanhoutte +1 more
TL;DR: This reviews pays special attention to microRNAs and their modulatory role in diabetes‐induced vascular dysfunction and some therapeutic strategies for preventing and restoring diabetic endothelial dysfunction are highlighted.
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FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)
TL;DR: The dual inhibition of FGF and CSF1 or VEGF signaling is expected to enhance the antitumor effects through the targeting of immune evasion and angiogenesis in the tumor microenvironment.
References
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Journal ArticleDOI
Activation of Tie2 by angiopoietin-1 and angiopoietin-2 results in their release and receptor internalization
TL;DR: Binding studies demonstrate that both ligands are differentially released from the endothelial cell surface after receptor activation and accumulate in the surrounding medium, and begin the understanding of the regulation of Tie2 and the activity of the angiopoietins after engaging the endotocyte cell surface.
Journal ArticleDOI
Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex.
William A. Barton,William A. Barton,Dorothea Tzvetkova-Robev,Edward P Miranda,Momchil V. Kolev,Kanagalaghatta R. Rajashankar,Juha P. Himanen,Dimitar B. Nikolov +7 more
TL;DR: Analysis of the structures and structure-based mutagenesis provide insight into the mechanism of receptor activation and support the hypothesis that all angiopoietins interact with Tie2 in a structurally similar manner.
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Specifically Targeting Angiopoietin-2 Inhibits Angiogenesis, Tie2-Expressing Monocyte Infiltration, and Tumor Growth
Hanhua Huang,Jing-Yu Lai,Janet Do,Dingguo Liu,Lingna Li,Joselyn Del Rosario,Venkata Doppalapudi,Steven Pirie-Shepherd,Nancy Levin,Curt W. Bradshaw,Gary Woodnutt,Rodney W. Lappe,Abhijit Bhat +12 more
TL;DR: CovX-Bodies provide an elegant solution to overcome the pharmacokinetic–pharmacodynamic problems of peptides and will be useful as single agents and in combination with standard-of-care agents.
Journal ArticleDOI
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
Mira C. Puri,Alan Bernstein +1 more
TL;DR: It is shown here that TIE receptors are not required for differentiation and proliferation of definitive hematopoietic lineages in the embryo and fetus; surprisingly, however, these receptors are specifically required during postnatal bone marrow hematoiesis.
Journal ArticleDOI
Mast cell–derived angiopoietin-1 plays a critical role in the growth of plasma cell tumors
TL;DR: It is demonstrated that mast cell-derived Ang-1 promotes the growth of plasmacytomas by stimulating neovascularization and provide further evidence supporting a causal relationship between inflammation and tumor growth.
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