Journal ArticleDOI
Angiopoietins in angiogenesis.
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TLDR
Its central role in the regulation of physiological and pathological angiogenesis makes the angiopoietin/Tie signaling pathway a therapeutically attractive target for the treatment of vascular disease and cancer.About:
This article is published in Cancer Letters.The article was published on 2013-01-01. It has received 528 citations till now. The article focuses on the topics: Angiopoietin & Angiopoietin receptor.read more
Citations
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Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer
TL;DR: Recent discoveries of new mechanisms underlying angiogenesis are examined, successes and challenges of current antiangiogenic therapy are discussed, and emerging antiangIogenic paradigms are highlighted.
Journal ArticleDOI
Diabetes and Wound Angiogenesis.
TL;DR: This review focuses on diabetic wound healing, paying special attention to the aberrations that have been described in the proliferative, remodeling, and maturation phases of wound angiogenesis and considers therapeutics that may offer promise to better wound healing outcomes.
Journal ArticleDOI
Small molecules in targeted cancer therapy: advances, challenges, and future perspectives.
Lei Zhong,Y. Li,Liang Xiong,Wen-Jing Wang,Ming Wu,Ting Yuan,Wei Yang,Chenyu Tian,Zhuang Miao,Tianqi Wang,Shengyong Yang +10 more
TL;DR: A comprehensive review of small-molecule targeted anti-cancer drugs according to the target classification is conducted, which presents all the approved drugs as well as important drug candidates in clinical trials for each target, and discusses the current challenges.
Journal ArticleDOI
Macro- and microvascular endothelial dysfunction in diabetes
Yi Shi,Paul M. Vanhoutte +1 more
TL;DR: This reviews pays special attention to microRNAs and their modulatory role in diabetes‐induced vascular dysfunction and some therapeutic strategies for preventing and restoring diabetic endothelial dysfunction are highlighted.
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FGFR inhibitors: Effects on cancer cells, tumor microenvironment and whole-body homeostasis (Review)
TL;DR: The dual inhibition of FGF and CSF1 or VEGF signaling is expected to enhance the antitumor effects through the targeting of immune evasion and angiogenesis in the tumor microenvironment.
References
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Journal ArticleDOI
Angiopoietin-1 Promotes Tumor Angiogenesis in a Rat Glioma Model
TL;DR: It is demonstrated by means of magnetic resonance imaging that increased hAng-1 expression promoted a significant in vivo growth of intracerebral gliomas in rats, and results indicate that in the presence of h Ang-1, tumors induce a more functional vascular network, which led to better tumor perfusion and growth.
Journal ArticleDOI
Angiopoietin-2 Interferes with Anti-VEGFR2–Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas
Sung-Suk Chae,Walid S. Kamoun,Christian T. Farrar,Nathaniel D. Kirkpatrick,Elisabeth Niemeyer,Annemarie M.A. de Graaf,A. Gregory Sorensen,Lance L. Munn,Rakesh K. Jain,Dai Fukumura +9 more
TL;DR: Cancer treatment regimens combining anti-VEGF and anti-Ang-2 agents may be an effective strategy to improve the efficacy of current anti–VEGF therapies in glioma patients.
Journal ArticleDOI
Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surface.
TL;DR: Differential regulation of angiopoietin binding allows control of Tie2 activation response to Ang1 without affecting Ang2 agonist activity and maintains the ability of Ang2 to antagonize even the enhanced Ang1 activation of tie2 that occurs on loss of Tie1 ectodomain.
Journal ArticleDOI
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
Hai Tao Yuan,Shivalingappa Venkatesha,Barden Chan,Urban Deutsch,Tadanori Mammoto,Vikas P. Sukhatme,Adrian S. Woolf,S. Ananth Karumanchi +7 more
TL;DR: It is shown that a main role for Tiel is to modulate blood vessel morphogenesis by virtue of its ability to down‐regulate Tie2‐driven signaling and endothelial survival.
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Molecular mechanisms and clinical applications of angiogenesis
Peter Carmeliet,Rakesh K. Jain +1 more