Anticancer activity expressed by a library of 2,9-diazaperopyrenium dications.
Karel J. Hartlieb,Leah S. Witus,Daniel P. Ferris,Ashish N. Basuray,Mohammed M. Algaradah,Amy A. Sarjeant,Charlotte L. Stern,Majed S. Nassar,Youssry Y. Botros,J. Fraser Stoddart +9 more
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TLDR
Investigations reveal that a number of 2,9-diazaperopyrenium dications show similar activities as doxorubicin toward a variety of cancer cell lines, and reports the solid-state structures of these dications, and relates their tendency to aggregate in solution to their toxicity profiles.Abstract:
Polyaromatic compounds are well-known to intercalate DNA. Numerous anticancer chemotherapeutics have been developed upon the basis of this recognition motif. The compounds have been designed such t...read more
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ExTzBox: A Glowing Cyclophane for Live-Cell Imaging
Indranil Roy,Sharan Bobbala,Jiawang Zhou,Minh T. Nguyen,Siva Krishna Mohan Nalluri,Yilei Wu,Daniel P. Ferris,Evan A. Scott,Michael R. Wasielewski,J. Fraser Stoddart +9 more
TL;DR: A simple, yet effective, strategy is introduced based on well-established chemistry for designing a new class of fluorescent probes for live-cell imaging that is non-cytotoxic to RAW 264.7 macrophages and allows the cells to glow brightly with blue laser excitation without any hint of photobleaching or disruption of normal cell behavior under the imaging conditions.
Journal ArticleDOI
Intramolecular Energy and Electron Transfer within a Diazaperopyrenium-Based Cyclophane
Xirui Gong,Ryan M. Young,Karel J. Hartlieb,Claire E. Miller,Yilei Wu,Hai Xiao,Peng Li,Nema Hafezi,Jiawang Zhou,Lin Ma,Tao Cheng,William A. Goddard,Omar K. Farha,Joseph T. Hupp,Michael R. Wasielewski,J. Fraser Stoddart +15 more
TL;DR: The synthesis, characterization, and photophysical properties of a rationally designed multichromophoric tetracationic cyclophane, DAPPBox4+, containing a diazaperopyrenium (DAPP2+) unit and an extended viologen (ExBIPY2%) unit, which are linked together by two p-xylylene bridges are reported on.
Journal ArticleDOI
Donor-acceptor single cocrystal of coronene and perylene diimide: molecular self-assembly and charge-transfer photoluminescence
TL;DR: In this paper, a successful molecular self-assembly design for the perylene-3,4,9,10-tetracarboxylic (PTCDI) cocrystal with a donor molecule, coronene, was reported.
Journal ArticleDOI
Toward a Charged Homo[2]catenane Employing Diazaperopyrenium Homophilic Recognition
Xirui Gong,Jiawang Zhou,Karel J. Hartlieb,Claire E. Miller,Peng Li,Omar K. Farha,Joseph T. Hupp,Ryan M. Young,Michael R. Wasielewski,J. Fraser Stoddart +9 more
TL;DR: It is shown that irradiation of the DAPPHC8+ catenane at 330 nm in acetonitrile solution results in simultaneous energy and electron transfer and the generation of a temporary charge-separated state within a rigid and robust homo[2]catenane.
Journal ArticleDOI
Concurrent Covalent and Supramolecular Polymerization.
Xisen Hou,Chenfeng Ke,Yu Zhou,Zhuang Xie,Ahmed Alngadh,Denis T. Keane,Majed S. Nassar,Youssry Y. Botros,Chad A. Mirkin,J. Fraser Stoddart +9 more
TL;DR: A concurrent covalent and supramolecular polymerization strategy-namely, one which utilizes a bis-azide-functionalized diazaperopyrenium dication that undergoes polymeriation covalently with a Bis-alkyne- functionalized biphenyl derivative in one dimension, resulting in an extended polymer network in an orthogonal dimension is described.
References
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