Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Antioxidants and antioxidant methods: an updated overview
TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
Journal ArticleDOI
Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors.
Serdar Burmaoglu,Serdar Burmaoglu,Ali Yilmaz,M. Fatih Polat,Ruya Kaya,İlhami Gülçin,Oztekin Algul +6 more
TL;DR: These derivatives' inhibitory potential on the tested enzymes are promising drug candidates for the treatment of diseases like glaucoma, leukemia, epilepsy; Alzheimer's disease; type-2 diabetes mellitus that are associated with high enzymatic activity of carbonic anhydrase, acetylcholine esterase, butyrylcholinesterases, and α-glycosidase.
Journal ArticleDOI
Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
Mansura Huseynova,Parham Taslimi,Ajdar Medjidov,Vagif Farzaliyev,Mahizar Aliyeva,Gulnar Gondolova,Onur Şahin,Bahattin Yalçın,Afsun Sujayev,Efe Baturhan Orman,Ali Rıza Özkaya,İlhami Gülçin +11 more
TL;DR: In this article, the thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against α-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylchioxomethyl)hydrazinyl] acetic acid (H2TAA) and acetylcholinesterase.
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The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities.
Parham Taslimi,Fatih Mehmet Kandemir,Yeliz Demir,Mustafa Ileriturk,Yusuf Temel,Cuneyt Caglayan,İlhami Gülçin +6 more
TL;DR: Results showed that CH exhibited an ameliorative effect against CYP‐induced brain, heart, liver, testis, and kidney toxicity.
Journal ArticleDOI
Photocatalytic degradation of Rhodamine B (RhB) dye in waste water and enzymatic inhibition study using cauliflower shaped ZnO nanoparticles synthesized by a novel One-pot green synthesis method
Shashanka Rajendrachari,Parham Taslimi,Abdullah Cahit Karaoglanli,Orhan Uzun,Orhan Uzun,Emre Alp,Gururaj Kudur Jayaprakash +6 more
TL;DR: In this article, the authors have prepared ZnO nanoparticles using Alchemilla vulgaris (Lady's mantle) leaves and investigated their anti-enzymatic properties, which showed the cumulative median particle size of 550nm.
References
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Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces apoptosis in human promyelocytic leukemia cells.
Hyo-Joung Seo,Young-Joon Surh +1 more
TL;DR: Eupatilin-induced HL-60 cell apoptosis does not appear to be mediated via alteration in Bcl-2/Bax-2.
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Increased Myeloproliferation in Glutathione S-Transferase π-deficient Mice Is Associated with a Deregulation of JNK and Janus Kinase/STAT Pathways
TL;DR: The increased activation of JNK and STATs in GSTπ-deficient mice provides a viable mechanism for the increased myeloproliferation in these animals, and confirms the important role that GSTπ plays in the regulation of cell signaling pathways in a myELoproliferative setting.
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Co-induction of glutathione-S-transferases and multidrug resistance associated protein by xenobiotics in wheat.
Frederica L. Theodoulou,Ian M. Clark,Xiao-Li He,Kenneth E. Pallett,David J. Cole,D. L. Hallahan +5 more
TL;DR: This work establishes herbicide safeners as useful tools for the identification of genes encoding herbicide-metabolising enzymes by investigating the effects of the safener cloquintocetmexyl, which protects small-grain cereals against the graminicidal herbicide, clodinafop-propargyl.
Journal ArticleDOI
Pancreatic α-amylase and lipase inhibitory activity of polyphenolic compounds present in the extract of black chokeberry (Aronia melanocarpa L.)
Paulina Worsztynowicz,Marta Napierała,Marta Napierała,Wojciech Białas,Włodzimierz Grajek,Mariola Olkowicz +5 more
TL;DR: In this paper, the authors investigated the effect of chokeberry extract on the activity of porcine pancreatic α-amylase and lipase and found that methanolic and acetic chokeberry extracts exhibited the highest inhibitory activities against α-AMylase with the IC 50 values of 10.31−±−0.04% and pancreatic lipase 83.45−±0.50% respectively.
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Rb2 inhibits α-glucosidase and regulates glucose metabolism by activating AMPK pathways in HepG2 cells
TL;DR: The enzyme kinetic studies revealed that, in the presence of the most potent α-glucosidase inhibitors, Rb2 and Rd, the Michaelis-Menton constant remained constant but the maximal velocity decreased, revealing a non-competitive type of inhibition.