Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Antioxidants and antioxidant methods: an updated overview
TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
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Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors.
Serdar Burmaoglu,Serdar Burmaoglu,Ali Yilmaz,M. Fatih Polat,Ruya Kaya,İlhami Gülçin,Oztekin Algul +6 more
TL;DR: These derivatives' inhibitory potential on the tested enzymes are promising drug candidates for the treatment of diseases like glaucoma, leukemia, epilepsy; Alzheimer's disease; type-2 diabetes mellitus that are associated with high enzymatic activity of carbonic anhydrase, acetylcholine esterase, butyrylcholinesterases, and α-glycosidase.
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Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
Mansura Huseynova,Parham Taslimi,Ajdar Medjidov,Vagif Farzaliyev,Mahizar Aliyeva,Gulnar Gondolova,Onur Şahin,Bahattin Yalçın,Afsun Sujayev,Efe Baturhan Orman,Ali Rıza Özkaya,İlhami Gülçin +11 more
TL;DR: In this article, the thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against α-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylchioxomethyl)hydrazinyl] acetic acid (H2TAA) and acetylcholinesterase.
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The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities.
Parham Taslimi,Fatih Mehmet Kandemir,Yeliz Demir,Mustafa Ileriturk,Yusuf Temel,Cuneyt Caglayan,İlhami Gülçin +6 more
TL;DR: Results showed that CH exhibited an ameliorative effect against CYP‐induced brain, heart, liver, testis, and kidney toxicity.
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Photocatalytic degradation of Rhodamine B (RhB) dye in waste water and enzymatic inhibition study using cauliflower shaped ZnO nanoparticles synthesized by a novel One-pot green synthesis method
Shashanka Rajendrachari,Parham Taslimi,Abdullah Cahit Karaoglanli,Orhan Uzun,Orhan Uzun,Emre Alp,Gururaj Kudur Jayaprakash +6 more
TL;DR: In this article, the authors have prepared ZnO nanoparticles using Alchemilla vulgaris (Lady's mantle) leaves and investigated their anti-enzymatic properties, which showed the cumulative median particle size of 550nm.
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Anti-diabetic, anti-hyperlipidemic and spermatogenic effects of Amaranthus spinosus Linn. on streptozotocin-induced diabetic rats
TL;DR: Some pharmacological evidence is established to support the folklore claim that it is used as an anti-diabetic and accelerated the process of spermatogenesis by increasing the sperm count and accessory sex organ weights.
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Inhibition of B(a)P induced strand breaks in presence of curcumin.
TL;DR: The protective effect of curcumin on B(a)P induced DNA damage in human peripheral blood lymphocyte cells appears to be sex dependent and there was no correlation between DNA damage and GST-Mu levels and levels of micronutrients namely Vitamins A, E and beta carotene.
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Transgenic tobacco plants overexpressing cotton glutathione S-transferase (GST) show enhanced resistance to methyl viologen.
TL;DR: Transgenic tobacco plants overexpressing Gst-cr1 were normal in growth and mature compared with control, but had much higher levels of GST and GPx activities and showed an enhanced resistance to oxidative stress induced by a low concentration of methyl viologen (MV).
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Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities
María Torres-Naranjo,Alírica I. Suárez,Alírica I. Suárez,Gianluca Gilardoni,Luis Cartuche,Paola Flores,Vladimir Morocho +6 more
TL;DR: Four of the nine isolated compounds exhibited strong inhibitory activity with IC50 values below 8 µM, much higher than acarbose (377 uM).
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Treatment with oligonol, a low-molecular polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism.
TL;DR: The present results suggest that oligonol has protective effects against ROS-related inflammation and excess lipid deposition in the type 2 diabetic liver.