Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Antioxidants and antioxidant methods: an updated overview
TL;DR: Antioxidants had a growing interest owing to their protective roles in food and pharmaceutical products against oxidative deterioration and in the body and against oxidative stress-mediated pathological processes as discussed by the authors, and many studies evaluating the antioxidant activity of various samples of research interest have been conducted.
Journal ArticleDOI
Synthesis and biological evaluation of novel tris-chalcones as potent carbonic anhydrase, acetylcholinesterase, butyrylcholinesterase and α-glycosidase inhibitors.
Serdar Burmaoglu,Serdar Burmaoglu,Ali Yilmaz,M. Fatih Polat,Ruya Kaya,İlhami Gülçin,Oztekin Algul +6 more
TL;DR: These derivatives' inhibitory potential on the tested enzymes are promising drug candidates for the treatment of diseases like glaucoma, leukemia, epilepsy; Alzheimer's disease; type-2 diabetes mellitus that are associated with high enzymatic activity of carbonic anhydrase, acetylcholine esterase, butyrylcholinesterases, and α-glycosidase.
Journal ArticleDOI
Synthesis, characterization, crystal structure, electrochemical studies and biological evaluation of metal complexes with thiosemicarbazone of glyoxylic acid
Mansura Huseynova,Parham Taslimi,Ajdar Medjidov,Vagif Farzaliyev,Mahizar Aliyeva,Gulnar Gondolova,Onur Şahin,Bahattin Yalçın,Afsun Sujayev,Efe Baturhan Orman,Ali Rıza Özkaya,İlhami Gülçin +11 more
TL;DR: In this article, the thiosemicarbazone of glyoxylic acid derivatives had effective inhibition against α-glycosidase, cytosolic carbonic anhydrase I and II isoenzymes, butyrylchioxomethyl)hydrazinyl] acetic acid (H2TAA) and acetylcholinesterase.
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The antidiabetic and anticholinergic effects of chrysin on cyclophosphamide-induced multiple organ toxicity in rats: Pharmacological evaluation of some metabolic enzyme activities.
Parham Taslimi,Fatih Mehmet Kandemir,Yeliz Demir,Mustafa Ileriturk,Yusuf Temel,Cuneyt Caglayan,İlhami Gülçin +6 more
TL;DR: Results showed that CH exhibited an ameliorative effect against CYP‐induced brain, heart, liver, testis, and kidney toxicity.
Journal ArticleDOI
Photocatalytic degradation of Rhodamine B (RhB) dye in waste water and enzymatic inhibition study using cauliflower shaped ZnO nanoparticles synthesized by a novel One-pot green synthesis method
Shashanka Rajendrachari,Parham Taslimi,Abdullah Cahit Karaoglanli,Orhan Uzun,Orhan Uzun,Emre Alp,Gururaj Kudur Jayaprakash +6 more
TL;DR: In this article, the authors have prepared ZnO nanoparticles using Alchemilla vulgaris (Lady's mantle) leaves and investigated their anti-enzymatic properties, which showed the cumulative median particle size of 550nm.
References
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Expression of glutathione-S-transferases alpha and pi in gastric cancer: a correlation with cisplatin resistance.
Yasuhiro Kodera,Ken-ichi Isobe,Masaji Yamauchi,Ken Kondo,Seiji Akiyama,Katsuki Ito,Izumi Nakashima,Hiroshi Takagi +7 more
TL;DR: A comparison of the drug-sensitivity findings with the results of immunoblotting revealed a weak but interesting correlation between the protein levels of GST-α and CDDP resistance, which could contribute to prediction of the clinical effects of CDDP in patients with gastric cancer.
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Influence of phloretin and 6-ketocholestanol on the skin permeation of sodium-fluorescein
TL;DR: The results indicate a positive effect of 6-ketocholestanol on the sodium-fluorescein diffusion in all skin types, whereas phloretin had no significant influence compared to the control in human skin while rat as well as in porcine skin after 30 h of diffusion.
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Investigation of the effects of cephalosporin antibiotics on glutathione S-transferase activity in different tissues of rats in vivo conditions in order to drug development research.
TL;DR: The inhibition effects of some antibiotics were investigated against GST obtained from albino-rats kidney, liver, and heart tissues, finding that almost all antibiotic groups of kidney tissues had higher GST activity at all hours than those of control groups, but it was higher only in heart tissues.
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The methoxylated flavones eupatorin and cirsiliol induce CYP1 enzyme expression in MCF7 cells.
TL;DR: Two flavones, eupatorin and cirsiliol, enhanced CYP1 enzyme activity in a concentration-dependent manner in MCF7 human breast adenocarcinoma cells and induces CYP 1 enzyme expression in cancer cells and is subsequently converted by CYp1B1 or CYP2A1 into an antiproliferative agent.
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The toxicological impact of some avermectins on human erythrocytes glutathione S-transferase enzyme.
TL;DR: Investigation of the inhibitory effects of avermectin derivatives such as abamectin, doramect in, eprinomectin, ivermECTin, and moxidectin showed significant inhibitory effect on the GST enzyme.