Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Synthesis, Characterization, Molecular Docking, Acetylcholinesterase and α‐Glycosidase Inhibition Profiles of Nitrogen‐Based Novel Heterocyclic Compounds
I Gulcin,Olga Petrova,Parham Taslimi,Svetlana F. Malysheva,Elena Yu. Schmidt,Lyubov N. Sobenina,Nina K. Gusarova,Boris A. Trofimov,B. Tuzun,Vagif Farzaliyev,Saleh Alwasel,Afsun Sujayev +11 more
TL;DR: In this paper , a series of nitrogen-based novel heterocyclic compounds were synthesized and characterized by elemental analysis, IR and NMR spectra, and they were evaluated against the acetylcholinesterase (AChE) and α-glycosidase enzymes.
Journal ArticleDOI
Cholinesterases, carbonic anhydrase inhibitory properties and in silico studies of novel substituted benzylamines derived from dihydrochalcones.
TL;DR: In this article, a series of novel urea, sulfamide and N,N-dipropargyl substituted benzylamines were synthesized from dihydrochalcones.
Journal ArticleDOI
Synthesis, Characterization, Enzyme Inhibitory Activity, and Molecular Docking Analysis of a New Series of Thiophene-Based Heterocyclic Compounds
TL;DR: In this paper, 1-Phenyl-3-(thiophen-2-yl)-1H-pyrazole-5-carboxamide derivatives were designed and evaluated for their in vitro enzyme inhibitory activities against AChE, butyrylcholinesterase (BChE), and glutathione S-transferase (GST).
Journal ArticleDOI
The inhibition profile of sesamol against α-glycosidase and acetylcholinesterase enzymes
TL;DR: The inhibitory effects of sesamol compound on acetylcholinesterase and α-glycosidase enzymes were evaluated and showed effective inhibition at low concentrations.
Journal ArticleDOI
Inhibition profiles of Voriconazole against acetylcholinesterase, α‐glycosidase, and human carbonic anhydrase I and II isoenzymes
TL;DR: The Voriconazole compound demonstrated excellent inhibitory effects against AChE and hCA isoforms I and II and the results make an important contribution to drug design and have pharmacological applications.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).