Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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New quinoxalin-1,3,4-oxadiazole derivatives: Synthesis, characterization, in vitro biological evaluations, and molecular modeling studies.
Roghieh Mirzazadeh,Mohammad Sadegh Asgari,Ebrahim Barzegari,Keyvan Pedrood,Maryam Mohammadi-Khanaposhtani,Maedeh Sherafati,Bagher Larijani,Hossein Rastegar,Hojjat Rahmani,Mohammad Mahdavi,Parham Taslimi,Eda M. Üç,İlhami Gülçin +12 more
TL;DR: In this article, a series of quinoxalin-1,3,4-oxadiazole (10a-l) derivatives was synthesized and evaluated against some metabolic enzymes including human carbonic anhydrase (hCA) isoenzymes I and II, cholinesterase (acetylcholineinesterases and butyrylcholinestersterase), and α-glucosidase.
Journal ArticleDOI
Secondary metabolites of Helichrysum plicatum DC. subsp. plicatum flowers as strong carbonic anhydrase, cholinesterase and α-glycosidase inhibitors
TL;DR: Helichrysum plicatum secondary metabolites demonstrated strong inhibitory effects especially against hCAI and hCAII, whereas the MeOH extract showed a weak inhibitory effect on all enzymes, according to in vitro human carbonic anhydrase I and II.
Journal ArticleDOI
Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE.
Mehmet Kadir Erdogan,İbrahim Halil Geçibesler,Yakup Yapar,Ramazan Gundogdu,Mahinur Kirici,Lütfi Behçet,Parham Taslimi +6 more
TL;DR: In this paper, the authors evaluated the antioxidant, enzyme inhibitory, and anticancer properties as well as fatty acid compositions of endemic Saponaria prostrata WILLD subsp anatolica.
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Evaluation of the neuropharmacological effects of Gardenin A in mice.
Angel Josabad Alonso-Castro,Deisy Gasca-Martínez,Laura V. Cortez-Mendoza,Clara Alba-Betancourt,Alan Joel Ruiz-Padilla,Juan Ramón Zapata-Morales +5 more
TL;DR: It is suggested that GA induces anxiolytic-like effects and has anticonvulsant actions by the possible involvement of the GABAergic system and the antidepressant-like actions of GA may be mediated by noradrenergic neurotransmission.
Journal ArticleDOI
Stevia Genus: Phytochemistry and Biological Activities Update.
TL;DR: A review of the Stevia genus covering ethnobotanical aspects and traditional uses, phytochemistry, and biological activities of the extracts and isolated compounds is presented in this paper.
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).