Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Novel zinc compound with thiosemicarbazone of glyoxylic acid: Synthesis, crystal structure, and bioactivity properties
Mansura Huseynova,Vaqif Farzaliyev,Ajdar Medjidov,Mahizar Aliyeva,Parham Taslimi,Onur Şahin,Bahattin Yalçın +6 more
TL;DR: Zn3C18H34N18O17S6 (1) was determined using single crystal X-ray diffraction methods as mentioned in this paper, which showed that the complex crystallized in a triclinic system with the space group P-1.
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Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase
Burcu Tezcan,Yetkin Gök,Resul Sevinçek,Parham Taslimi,Tugba Taskin-Tok,Aydın Aktaş,Bilgehan Güzel,Muhittin Aygün,İlhami Gülçin +8 more
TL;DR: From the absorption, distribution, metabolism, excretion, and toxicity analyses, it can be concluded that the compounds under consideration exhibited more drug‐likeness properties in the prediction studies compared to positive controls.
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Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects
Hasan Karagecili,Mustafa Yilmaz,Adem Ertürk,Hatice Kızıltaş,Leyla Güven,Saleh Alwasel,I Gulcin +6 more
TL;DR: In this article , the chemical composition and antioxidant activities of propolis were investigated; ABTS•+, DPPH• and DMPD•+ were prepared using radical scavenging antioxidant methods.
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Novel quinazolin-sulfonamid derivatives: synthesis, characterization, biological evaluation, and molecular docking studies.
Nima Sepehri,Maryam Mohammadi-Khanaposhtani,Nafise Asemanipoor,Samanesadat Hosseini,Mahmood Biglar,Bagher Larijani,Mohammad Mahdavi,Haleh Hamedifar,Parham Taslimi,Nastaran Sadeghian,Mostafa Norizadehtazehkand,İlhami Gülçin +11 more
TL;DR: These synthesized novel quinazolin–sulfonamid derivatives (9a–m) were found to be effective inhibitor molecules for the α-glycosidase, human carbonic anhydrase I and II, butyrylcholinesterase (BChE) and acetylcholinerase (AChE), with Ki values in the range of 100.
Journal ArticleDOI
Nimesulide linked acyl thioureas potent carbonic anhydrase I, II and α-glucosidase inhibitors: Design, synthesis and molecular docking studies
Atteeque Ahmed,Imran Shafique,Aamer Saeed,Ghulam Shabir,Arslan Saleem,Parham Taslimi,Tugba Taskin Tok,Mahinur Kirici,E. Üç,Muhammad Zaffar Hashmi +9 more
TL;DR: In this paper , 14 derivatives of Nimesulide were synthesized and tested for carbonic anhydrase I, II and α-glucosidase Inhibition assay.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).