Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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In vitro α-amylase and hemoglobin glycation inhibitory potential of Nigella sativa essential oil, and molecular docking studies of its principal components
Mohammed Dalli,Nour Elhouda Daoudi,Farid Abrigach,Salah Azizi,Mohamed Bnouham,Bong-Hee Kim,Nadia Gseyra +6 more
TL;DR: Molecular docking studies against human pancreatic α-amylase and human hemoglobin enzymes revealed that these compounds can serve as lead molecules to develop new antidiabetic compounds.
Journal ArticleDOI
Identification of α-amylase inhibitory compounds from leaves of Careya arborea Roxb. and in silico docking studies
TL;DR: In this article , secondary metabolites present in chloroform leaf extract of Careya arborea Roxb were identified with Liquid Chromatography-Mass Spectrometry (LC-MS/MS) and docked with PPA structure using AutoDock 4.2.
Journal ArticleDOI
Synthesis characterization and evaluation of novel triazole based analogs as a acetylcholinesterase and α-glucosidase inhibitors
Hafiz M. A. Asif,Shagufta Kamal,Aziz-ur-Rehman,Ismat Bibi,Najla AlMasoud,Taghrid S. Alomar,Munawar Iqbal +6 more
TL;DR: A series of novel triazole analogs (10a-k) bearing piperidine were synthesized in an aprotic solvent on the most effective pharmacophore with acetylcholinesterase (AChE) and α-glucosidase inhibitory activity as mentioned in this paper .
Journal ArticleDOI
Chemical composition, antioxidant and enzyme inhibitory properties of Ajuga parviflora Benth.
TL;DR: In this paper, the authors evaluated the inhibitory potential of A. parviflora extracts against carbohydrate-hydrolyzing enzymes linked with hyperglycemia and the effect of extracts on glucose uptake by the yeast cells by in-vitro means.
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Polyphenolic profile and pharmacological activities of whips horse (Luehea divaricata) bark extracts studied using in vitro and in vivo systems
Jéssica A.A Garcia Manieri,Vanesa Gesser Correa,Rúbia Carvalho Gomes Corrêa,Maria Inês Dias,Ricardo C. Calhelha,Marija Ivanov,Marina Soković,Lillian Barros,Isabel C.F.R. Ferreira,Adelar Bracht,Rosane Marina Peralta +10 more
TL;DR: In this article , the authors presented in vivo experiments (rats and mice) supported by in vitro and chemical analyses in order to address the above mentioned folk medicinal uses, which confirmed the vox populi claims about the therapeutic actions of the species.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).