Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Imidazolinium chloride salts bearing wingtip groups: Synthesis, molecular docking and metabolic enzymes inhibition
Beyhan Yiğit,Ruya Kaya,Ruya Kaya,Parham Taslimi,Yılmaz Işık,Muhammet Karaman,Murat Yigit,İsmail Özdemir,İlhami Gülçin +8 more
TL;DR: A series of symmetrical imidazolinium chloride salts bearing secondary N-alkyl substituents were synthesized in good yield by the reaction of N,N′-dialkylethane-1,2-diamines and HC(OEt)3 in the presence of NH4Cl, characterized by spectroscopic methods.
Journal ArticleDOI
Synthesis and characterization of novel bromophenols: Determination of their anticholinergic, antidiabetic and antioxidant activities
TL;DR: The antioxidant capacity of novel bromophenol derivatives is examined using several in vitro bioanalytical methodologies such as 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) and 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH) radical scavenging activity, Fe3+ and Cu2+ reducing activities and ferrous ions chelating activities.
Journal ArticleDOI
Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
İlhami Gülçin,Ruya Kaya,Ahmet C. Gören,Hulya Akincioglu,Meryem Topal,Zeynebe Bingol,Kader Cetin Cakmak,Sevim Beyza Öztürk Sarikaya,Lokman Durmaz,Saleh Alwasel +9 more
TL;DR: Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods.
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Anticholinergic, antidiabetic and antioxidant activities of Anatolian pennyroyal (Mentha pulegium)-analysis of its polyphenol contents by LC-MS/MS
TL;DR: In this paper, methanolic and water extracts of pennyroyal (Mentha pulegium) were evaluated for their antioxidant profiles by eight distinguished bioanalytical methods and for their inhibitory effects against enzymes linked to different diseases.
Journal ArticleDOI
Novel eugenol bearing oxypropanolamines: Synthesis, characterization, antibacterial, antidiabetic, and anticholinergic potentials.
Hayriye Genc Bilgicli,Ali Kestane,Parham Taslimi,Oguz Karabay,Arlinda Bytyqi-Damoni,Mustafa Zengin,İlhami Gülçin +6 more
TL;DR: Five oxypropanol amine derivatives that four of them are novel have been synthesized with high yields and practical methods and it was concluded that these compounds are much more effective than reference drugs.
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).