Journal ArticleDOI
Antidiabetic and antiparasitic potentials: Inhibition effects of some natural antioxidant compounds on α-glycosidase, α-amylase and human glutathione S-transferase enzymes
İlhami Gülçin,Parham Taslimi,Ayşenur Aygün,Nastaran Sadeghian,Enes Bastem,Ömer İrfan Küfrevioğlu,Fikret Türkan,Fatih Şen +7 more
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TLDR
These molecules can be elective inhibitors of GST, α-glycosidase and α-amylase enzymes as antidiabetic and antiparasitic agents and demonstrate effective inhibitor compounds with Ki values in the range of 8.34-40.78 μM against GST, and 120.53-892.36 nM against α- Glycosid enzyme.About:
This article is published in International Journal of Biological Macromolecules.The article was published on 2018-11-01. It has received 158 citations till now. The article focuses on the topics: Antiparasitic agent & Glutathione S-transferase.read more
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Biological Activity and Molecular Docking Study of Some Bicyclic Structures: Antidiabetic and Anticholinergic Potentials
Parham Taslimi,Fidan N. Akhundova,Malahat M. Kurbanova,Fikret Türkan,Burak Tüzün,Afsun Sujayev,Nastaran Sadeghian,Nastaran Sadeghian,Abel M. Maharramov,Vagif Farzaliyev,İlhami Gülçin +10 more
TL;DR: Bicyclic structures were synthesized by LACASA-DA cycloaddition reaction using (S)-BINOL as a chiral inductor to protect the N-2 pyridazine position and form the hydroxyl group.
Journal ArticleDOI
Determination of LC-HRMS Profiling, Antioxidant Activity, Cytotoxic Effect and Enzyme Inhibitory Properties of Satureja avromanica using in vitro and in silico methods
TL;DR: In this paper , some biochemical properties of Satureja avromanica, such as phenolic content, anticholinergic, antidiabetic and antioxidant activities were determined, and the antioxidant capacities of EESA and WESA were evaluated by six different antioxidant methods.
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Omnifarious fruit polyphenols: an omnipotent strategy to prevent and intervene diabetes and related complication?
TL;DR: In this article, a comprehensive review on polyphenols from the edible parts of fruits, including those from citrus, berries, apples, cherries, mangoes, mangosteens, pomegranates, and other fruits regarding their potential benefits in preventing and treating diabetes mellitus is presented.
Journal ArticleDOI
Multivariate Analyses of the Antioxidant, Antidiabetic, Antimicrobial Activity of Pomegranate Tissues with Respect to Pomegranate Juice
TL;DR: The pomegranate peel (PP), seed (PS), mesocarp (PM), and juice (PJ) was analyzed in this paper, and the total contents of phenolics (TPC), flavonoids (TFC), and hydrolysable tannins (HTC) were analyzed.
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Trimethylsilyl chloride catalyzed synthesis of fluoro substituted tetrahydropyrimidines: Molecular docking and antidiabetic studies
TL;DR: In this article , a series of tetrahydropyrimidine derivatives containing azepino indole and aryl substitution was achieved by a multicomponent synthetic approach using Biginelli condensation.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Glutathione S-transferases. The first enzymatic step in mercapturic acid formation.
TL;DR: The purification of homogeneous glutathione S-transferases B and C from rat liver is described, and only transferases A and C are immunologically related.
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The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).