Journal ArticleDOI
Antimicrobial peptides (AMPs) as drug candidates: a patent review (2003-2015).
Paulina Kosikowska,Adam Lesner +1 more
Reads0
Chats0
TLDR
The article highlights the general trends in the design, potential mode of action, and methods of biological evaluation of AMPs.Abstract:
Introduction: Antimicrobial peptides (AMPs) represent the large group of endogenous compounds widely distributed in nature. Due to their broad spectrum of antibiotic activity, as well as anti-inflammatory and immunomodulatory properties, AMPs became a model for the discovery of novel antimicrobial drugs that could answer the problem of the increasing antibiotic resistance of pathogenic microorganisms.Areas covered: The review represents a comprehensive analysis of patents and patent applications from the year 2003 to 2015 referring to the therapeutic use of AMPs. The article highlights the general trends in the design, potential mode of action, and methods of biological evaluation of AMPs.Expert opinion: The existing discord between the upcoming list of antimicrobial peptides claimed in the patents or related scientific articles as the potent drug candidates and the frequent failures of AMPs in clinical trials emphasize the need of a better understanding of their pleiotropic nature and mechanisms ...read more
Citations
More filters
Journal ArticleDOI
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents
Margit Mahlapuu,Margit Mahlapuu,Joakim Håkansson,Lovisa Ringstad,Camilla Björn,Camilla Björn +5 more
TL;DR: An overview of the biological role, classification, and mode of action of AMPs is provided, the opportunities and challenges to develop these peptides for clinical applications are discussed, and the innovative formulation strategies for application are reviewed.
Journal ArticleDOI
The value of antimicrobial peptides in the age of resistance
Maria Magana,Muthuirulan Pushpanathan,Ana L. Santos,Leon G. Leanse,Michael Fernandez,Anastasios Ioannidis,Marc A. Giulianotti,Yiorgos Apidianakis,Steven B. Bradfute,Andrew L. Ferguson,Artem Cherkasov,Mohamed N. Seleem,Clemencia Pinilla,Cesar de la Fuente-Nunez,Themis Lazaridis,Themis Lazaridis,Tianhong Dai,Richard A. Houghten,Robert E. W. Hancock,George P. Tegos +19 more
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
Journal ArticleDOI
Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
TL;DR: Focus is on the developments reported in the last decade of peptidomimetics with a modular structure of residues connected via amide linkages with respect to their design, synthesis, antimicrobial activity, cytotoxic side effects as well as their potential applications as anti-infective agents.
Journal ArticleDOI
Antibiotic resistance breakers: current approaches and future directions
TL;DR: It is posit that the broader field of ARB research can yet yield a greater diversity of more effective therapeutic agents than have been previously achieved, and offers a perspective on the future direction of the field.
Journal ArticleDOI
Considerations and Caveats in Combating ESKAPE Pathogens against Nosocomial Infections
Yu Xuan Ma,Chen yu Wang,Yuanyuan Li,Jing Li,Qian Qian Wan,Ji Hua Chen,Franklin R. Tay,Li Na Niu,Li Na Niu +8 more
TL;DR: A broad overview of the antimicrobial research on ESKAPE pathogens over the past five years is provided with prospective clinical applications.
References
More filters
Journal ArticleDOI
Mechanisms of Antimicrobial Peptide Action and Resistance
TL;DR: The intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance.
Journal ArticleDOI
Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.
Journal ArticleDOI
Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor
TL;DR: A family of peptides with broad-spectrum antimicrobial activity has been isolated from the skin of the African clawed frog Xenopus laevis and appears to represent a previously unrecognized class of vertebrate antimicrobial activities.
Journal ArticleDOI
The Future of Peptide‐based Drugs
TL;DR: The suite of currently used drugs can be divided into two categories - traditional'small molecule' drugs with typical molecular weights of 5000 Da that are not orally bioavailable and need to be delivered via injection as mentioned in this paper.
Journal ArticleDOI
Sequence and specificity of two antibacterial proteins involved in insect immunity
TL;DR: It is believed that P9A and P9B play an important part in the humoral immune responses described previously and that the P9 proteins represent a new class of antibacterial agents for which the name cecropins is proposed.