Antioxidant activity and apoptotic induction as mechanisms of action of Withania somnifera (Ashwagandha) against a hepatocellular carcinoma cell line.
TLDR
Ashwagandha could be a powerful antioxidant and a promising anticancer agent against HCC.Abstract:
ObjectiveTo evaluate the antioxidant and apoptotic inductive effects of Withania somnifera (Ashwagandha) leaf extract against a hepatocellular carcinoma cell line.MethodsAfter treating HepG2cells w...read more
Citations
More filters
Journal ArticleDOI
Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
TL;DR: A comprehensive review of the properties of WS extracts (WSE) containing complex mixtures of diverse components including WFA, which have shown inhibitory properties against many cancers, along with their mechanism of actions and pathways involved.
Journal ArticleDOI
Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects.
Subhabrata Paul,Shreya Chakraborty,Uttpal Anand,Swarnali Dey,Samapika Nandy,Mimosa Ghorai,Suchismita Chatterjee Saha,Manoj Patil,Ramesh Kandimalla,Jarosław Proćków,Abhijit Dey +10 more
TL;DR: In this article, a comprehensive summary of the geographical distribution, traditional use, phytochemistry, and pharmacological activities of W. somnifera and its active constituents are presented.
Journal ArticleDOI
Withania somnifera (L.) Dunal: A potential therapeutic adjuvant in cancer.
Akash Saggam,Girish Tillu,Santosh Dixit,Preeti Chavan-Gautam,Swapnil P. Borse,Kalpana Joshi,Bhushan Patwardhan +6 more
TL;DR: The experimentally-supported evidence of immunomodulatory, anti-cancer, adaptogenic, and regenerative attributes of WS suggest its therapeutic adjuvant potential in cancer management.
Journal ArticleDOI
Role of ashwagandha methanolic extract in the regulation of thyroid profile in hypothyroidism modeled rats
Khaled G. Abdel-Wahhab,Hagar H Mourad,Fathia A. Mannaa,Fatma A Morsy,Laila K Hassan,Rehab F Taher +5 more
TL;DR: It is concluded that ashwagandha methanolic extract treatment improves thyroid function by ameliorating thyroid hormones and by preventing oxidative stress.
Journal ArticleDOI
Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis
Jorge Pérez-Gómez,Santos Villafaina,Jose C. Adsuar,Eugenio Merellano-Navarro,Daniel Collado-Mateo +4 more
TL;DR: In conclusion, Ashwagandha supplementation might improve the VO2max in athlete and non-athlete people, however, further research is need to confirm this hypothesis since the number of studies is limited and the heterogeneity was high.
References
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
Apoptosis: A Review of Programmed Cell Death
TL;DR: The goal of this review is to provide a general overview of current knowledge on the process of apoptosis including morphology, biochemistry, the role of apoptoses in health and disease, detection methods, as well as a discussion of potential alternative forms of apoptotic proteins.
Journal ArticleDOI
Free radicals, antioxidants and functional foods: Impact on human health
TL;DR: The present review provides a brief overview on oxidative stress mediated cellular damages and role of dietary antioxidants as functional foods in the management of human diseases.
Related Papers (5)
Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells.
Sajida,Ashwini Prabhu +1 more