Antioxidant and Neuroprotective Activity of Extra Virgin Olive Oil Extracts Obtained from Quercetano Cultivar Trees Grown in Different Areas of the Tuscany Region (Italy).
Maria Cristina Barbalace,Lorenzo Zallocco,Daniela Beghelli,Maurizio Ronci,Serena Scortichini,Maria Digiacomo,Marco Macchia,Maria Rosa Mazzoni,Dennis Fiorini,Antonio Lucacchini,Silvana Hrelia,Laura Giusti,Cristina Angeloni +12 more
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TLDR
In this article, the potential antioxidant and neuroprotective activity of two different EVOO extracts obtained from Quercetano cultivar trees grown in two different areas (plain and hill) of the Tuscany region (Italy).Abstract:
Neurodegenerative diseases are driven by several mechanisms such as inflammation, abnormal protein aggregation, excitotoxicity, mitochondrial dysfunction and oxidative stress. So far, no therapeutic strategies are available for neurodegenerative diseases and in recent years the research is focusing on bioactive molecules present in food. In particular, extra-virgin olive oil (EVOO) phenols have been associated to neuroprotection. In this study, we investigated the potential antioxidant and neuroprotective activity of two different EVOO extracts obtained from Quercetano cultivar trees grown in two different areas (plain and hill) of the Tuscany region (Italy). The different geographical origin of the orchards influenced phenol composition. Plain extract presented a higher content of phenyl ethyl alcohols, cinnammic acids, oleacein, oleocanthal and flavones; meanwhile, hill extract was richer in lignans. Hill extract was more effective in protecting differentiated SH-SY5Y cells from peroxide stress thanks to a marked upregulation of the antioxidant enzymes heme oxygenase 1, NADPH quinone oxidoreductase 1, thioredoxin Reductase 1 and glutathione reductase. Proteomic analysis revealed that hill extract plays a role in the regulation of proteins involved in neuronal plasticity and activation of neurotrophic factors such as BDNF. In conclusion, these data demonstrate that EVOOs can have important neuroprotective activities, but these effects are strictly related to their specific phenol composition.read more
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New Mechanisms of Action of Natural Antioxidants in Health and Disease.
Silvana Hrelia,Cristina Angeloni +1 more
TL;DR: Natural antioxidants have been proposed to have beneficial effects on health and on different disease states, such as neurodegenerative and cardiovascular diseases, diabetes and cancer.
Journal ArticleDOI
Therapeutic Properties and Use of Extra Virgin Olive Oil in Clinical Nutrition: A Narrative Review and Literature Update
A Jiménez-Sánchez,Antonio Martínez-Ortega,Pablo Remón-Ruiz,A. Piñar-Gutiérrez,José Luis Pereira-Cunill,Pedro Pablo García-Luna +5 more
TL;DR: Current evidence supports the use of whole EVOO in diet therapy and the supplementation of its minor components to improve cardiovascular health, lipoprotein metabolism, and diabetes mellitus in clinical nutrition.
Journal ArticleDOI
Pterostilbene Promotes Mean Lifespan in Both Male and Female Drosophila Melanogaster Modulating Different Proteins in the Two Sexes
Daniela Beghelli,Lorenzo Zallocco,Maria Cristina Barbalace,Simona Paglia,Silvia Strocchi,Ilenia Cirilli,Valeria Marzano,Lorenza Putignani,Giulio Lupidi,Silvana Hrelia,Laura Giusti,Cristina Angeloni +11 more
TL;DR: A potential role of pterostilbene is suggested in increasing lifespan both in male and female flies by mechanisms that seem to be different in the two sexes, highlighting the need to conduct nutraceutical supplementation studies on males and females separately in order to give more reliable results.
Journal ArticleDOI
Extra Virgin Olive Oil Extracts of Indigenous Southern Tuscany Cultivar Act as Anti-Inflammatory and Vasorelaxant Nutraceuticals
Luca Pozzetti,Francesca Ferrara,Ludovica Marotta,Sandra Gemma,Stefania Butini,Mascia Benedusi,Fabio Fusi,Amer Ahmed Balla Ahmed,Serena Pomponi,Stefano Ferrari,Matteo Perini,Anna Ramunno,Giacomo Pepe,Pietro Campiglia,Giuseppe Valacchi,Gabriele Carullo,Giuseppe Campiani +16 more
TL;DR: In this article , autochthonous Tuscany EVOOs were chemically characterized and selected EVOO samples were extracted to obtain hydroalcoholic phytocomplexes, which were assayed to establish their anti-inflammatory and vasorelaxant properties.
Journal ArticleDOI
Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
Cristina Angeloni,Marco Malaguti,Cecilia Prata,Michela Freschi,Maria Cristina Barbalace,Silvana Hrelia +5 more
TL;DR: In this article , a review of the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates, is presented.
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