Mechanisms Underlying Neurodegenerative Disorders and Potential Neuroprotective Activity of Agrifood By-Products
Cristina Angeloni,Marco Malaguti,Cecilia Prata,Michela Freschi,Maria Cristina Barbalace,Silvana Hrelia +5 more
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TLDR
In this article , a review of the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates, is presented.Abstract:
Neurodegenerative diseases, characterized by progressive loss in selected areas of the nervous system, are becoming increasingly prevalent worldwide due to an aging population. Despite their diverse clinical manifestations, neurodegenerative diseases are multifactorial disorders with standard features and mechanisms such as abnormal protein aggregation, mitochondrial dysfunction, oxidative stress and inflammation. As there are no effective treatments to counteract neurodegenerative diseases, increasing interest has been directed to the potential neuroprotective activities of plant-derived compounds found abundantly in food and in agrifood by-products. Food waste has an extremely negative impact on the environment, and recycling is needed to promote their disposal and overcome this problem. Many studies have been carried out to develop green and effective strategies to extract bioactive compounds from food by-products, such as peel, leaves, seeds, bran, kernel, pomace, and oil cake, and to investigate their biological activity. In this review, we focused on the potential neuroprotective activity of agrifood wastes obtained by common products widely produced and consumed in Italy, such as grapes, coffee, tomatoes, olives, chestnuts, onions, apples, and pomegranates.read more
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Agri-Food Wastes as Natural Source of Bioactive Antioxidants
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Sepanlou,Edson Serván-Mori,Seyedmojtaba Seyedmousavi,Hosein Shabaninejad,Katya Anne Shackelford,Azadeh Shafieesabet,Mehdi Shahbazi,Amira Shaheen,Masood Ali Shaikh,Mehran Shams-Beyranvand,MohammadBagher Shamsi,Morteza Shamsizadeh,Kiomars Sharafi,Mehdi Sharif,Mahdi Sharif-Alhoseini,Rajesh Sharma,Jun She,Aziz Sheikh,Peilin Shi,Mekonnen Sisay Shiferaw,Mika Shigematsu,Rahman Shiri,Reza Shirkoohi,Ivy Shiue,Farhad Shokraneh,Mark G Shrime,Si Si,Soraya Siabani,Tariq Jamal Siddiqi,Inga Dora Sigfusdottir,Rannveig Sigurvinsdottir,Donald H. Silberberg,Diego Augusto Santos Silva,João Pedro Silva,Natacha Torres Da Silva,Dayane Gabriele Alves Silveira,Jasvinder A. Singh,Narinder Pal Singh,Prashant Singh,Virendra Singh,Dhirendra N Sinha,Karen Sliwa,Mari Smith,Badr Hasan Sobaih,Soheila Sobhani,Eugene Sobngwi,Samir Soneji,Moslem Soofi,Reed J D Sorensen,Joan B. Soriano,Ireneous N. Soyiri,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vinay Srinivasan,Jeffrey D. Stanaway,Vladimir I. 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Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Irfan Ullah,Eduardo A. Undurraga,Rachel L Updike,Muhammad Usman,Olalekan A. Uthman,Selen Begüm Uzun,Muthiah Vaduganathan,Afsane Vaezi,Gaurang Vaidya,Pascual R. Valdez,Elena Varavikova,Tommi Vasankari,Narayanaswamy Venketasubramanian,Santos Villafaina,Francesco Saverio Violante,Sergey K Vladimirov,Vasily Vlassov,Stein Emil Vollset,Theo Vos,Gregory R. Wagner,Fasil Wagnew,Yasir Waheed,Mitchell T. Wallin,Judd L. Walson,Yanping Wang,Yuan-Pang Wang,Molla Mesele Wassie,Elisabete Weiderpass,Robert G. Weintraub,Fitsum Weldegebreal,Kidu Gidey Weldegwergs,Andrea Werdecker,Adhena Ayaliew Werkneh,T. Eoin West,Ronny Westerman,Harvey Whiteford,Justyna Widecka,Lauren B. Wilner,Shadrach Wilson,Andrea Sylvia Winkler,Charles Shey Wiysonge,Charles D.A. Wolfe,Shouling Wu,Yun-Chun Wu,Grant M A Wyper,Denis Xavier,Gelin Xu,Simon Yadgir,Ali Yadollahpour,Seyed Hossein Yahyazadeh Jabbari,Bereket Yakob,Lijing L. Yan,Yuichiro Yano,Mehdi Yaseri,Yasin Jemal Yasin,Gokalp Kadri Yentur,Alex Yeshaneh,Ebrahim M Yimer,Paul S. F. Yip,Biruck Desalegn Yirsaw,Engida Yisma,Naohiro Yonemoto,Gerald Yonga,Seok Jun Yoon,Marcel Yotebieng,Mustafa Z. Younis,Mahmoud Yousefifard,Chuanhua Yu,Vesna Zadnik,Zoubida Zaidi,Sojib Bin Zaman,Mohammad Zamani,Zohreh Zare,Ayalew Jejaw Zeleke,Zerihun Menlkalew Zenebe,Anthony Lin Zhang,Kai Zhang,Maigeng Zhou,Sanjay Zodpey,Liesl Zühlke,Mohsen Naghavi,Christopher J L Murray +1028 more
TL;DR: Non-communicable diseases comprised the greatest fraction of deaths, contributing to 73·4% (95% uncertainty interval [UI] 72·5–74·1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional causes accounted for 18·6% (17·9–19·6), and injuries 8·0% (7·7–8·2).
Journal ArticleDOI
Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.