Antiretroviral Therapy for the Prevention of HIV-1 Transmission
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Leslie Cottle,Xinyi C. Zhang,Joseph Makhema,Lisa A. Mills,Ravindre Panchia,Sharlaa Faesen,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Max Essex,Sarah E. Hudelson,Andrew D. Redd,Thomas R. Fleming +35 more
Reads0
Chats0
TLDR
The early initiation of ART led to a sustained decrease in genetically linked HIV-1 infections in sexual partners, and was associated with a 93% lower risk of linked partner infection than was delayed ART.Abstract:
BackgroundAn interim analysis of data from the HIV Prevention Trials Network (HPTN) 052 trial showed that antiretroviral therapy (ART) prevented more than 96% of genetically linked infections caused by human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples. ART was then offered to all patients with HIV-1 infection (index participants). The study included more than 5 years of follow-up to assess the durability of such therapy for the prevention of HIV-1 transmission. MethodsWe randomly assigned 1763 index participants to receive either early or delayed ART. In the early-ART group, 886 participants started therapy at enrollment (CD4+ count, 350 to 550 cells per cubic millimeter). In the delayed-ART group, 877 participants started therapy after two consecutive CD4+ counts fell below 250 cells per cubic millimeter or if an illness indicative of the acquired immunodeficiency syndrome (i.e., an AIDS-defining illness) developed. The primary study end point was the diagnosis of genetically linked H...read more
Citations
More filters
Journal ArticleDOI
Sexually Transmitted Infections Among HIV-Infected Individuals in the District of Columbia and Estimated HIV Transmission Risk: Data From the DC Cohort.
Jose Lucar,Jose Lucar,Jose Lucar,Rachel Hart,Nabil Rayeed,Arpi Terzian,Amy C. Weintrob,Amy C. Weintrob,Marc O. Siegel,David M. Parenti,Leah E. Squires,Leah E. Squires,Rush Williams,Rush Williams,Amanda D. Castel,Debra Benator,Debra Benator +16 more
TL;DR: STIs are highly prevalent among HIV-infected persons receiving care in DC and interventions toward risk reduction, antiretroviral therapy adherence, and HIV virologic suppression are critical at the time of STI evaluation.
Journal ArticleDOI
Viral Infections and Obesity.
TL;DR: The evidence for a role in the genesis of obesity for viral agents in five broad categories is addressed: adenoviridae, herpesviridae, phages, transmissible spongiform encephalopathies (slow virus), and other encephalitides and hepatitides.
Journal ArticleDOI
Screening for HIV Infection in Asymptomatic, Nonpregnant Adolescents and Adults: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force
TL;DR: New evidence extends effectiveness of ART to asymptomatic individuals with CD4 cell counts greater than 500/mm3 and shows sustained reduction in risk of HIV transmission at longer-term follow-up, although certain ART regimens may be associated with increased risk of long-term harms.
Journal ArticleDOI
Virologic outcomes in early antiretroviral treatment: HPTN 052.
Susan H. Eshleman,Ethan Wilson,Xinyi C. Zhang,San San Ou,Estelle Piwowar-Manning,Joseph J. Eron,Marybeth McCauley,Theresa Gamble,Joel E. Gallant,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Ben Kalonga,José Henrique Pilotto,Beatriz Grinsztejn,Sheela Godbole,Nuntisa Chotirosniramit,Breno Santos,Emily Shava,Lisa A. Mills,Ravindre Panchia,Noluthando Mwelase,Kenneth H. Mayer,Ying Q. Chen,Myron S. Cohen,Jessica M. Fogel +25 more
TL;DR: Several clinical and demographic factors were identified that were associated with longer time to viral suppression and virologic failure in participants who initiated ART in HPTN 052 and recognition of these factors may help optimize ART for HIV treatment and prevention.
Journal ArticleDOI
The Metropolitan Atlanta community adolescent rapid testing initiative study: closing the gaps in HIV care among youth in Atlanta, Georgia, USA.
Andres Camacho-Gonzalez,Scott Gillespie,LaTeshia Thomas-Seaton,Krystal Frieson,Sophia A. Hussen,Ashley Murray,Zaneta Gaul,Traci Leong,Chanda Graves,Madeline Y. Sutton,Rana Chakraborty +10 more
TL;DR: MACARTI may serve as an effective linkage and care model for clinics serving HIV-infected youth as well as a pilot single-center, prospective, nonrandomized study.
References
More filters
Journal ArticleDOI
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
Journal ArticleDOI
Prevention of HIV-1 infection with early antiretroviral therapy
TL;DR: The exciting evidence generated by this paper – that antiretroviral treatment of HIV-1 infection definitively reduces the risk of onward transmission of the virus by 96% – was rightly dubbed Science magazine's ‘Breakthrough of the Year’ in 2011.
Journal ArticleDOI
Viral Load and Heterosexual Transmission of Human Immunodeficiency Virus Type 1
Thomas C. Quinn,Maria J. Wawer,Nelson K. Sewankambo,David Serwadda,Chuanjun Li,Fred Wabwire-Mangen,Mary Meehan,Tom Lutalo,Ronald H. Gray +8 more
TL;DR: The viral load is the chief predictor of the risk of heterosexual transmission of HIV-1, and transmission is rare among persons with levels of less than 1500 copies of HIV -1 RNA per milliliter.
Journal ArticleDOI
Initiation of antiretroviral therapy in early asymptomatic HIV infection
Sean Emery,Shweta Sharma,Gerd Fätkenheuer,Josep M. Llibre,Jean-Michel Moli,Paula Munderi,Robin Wood,Karin L. Klingman,Simon Collins,H. Clifford Lane,Andrew N. Phil,James D. Neaton +11 more
TL;DR: The initiation of antiretroviral therapy in HIV-positive adults with a CD4+ count of more than 500 cells per cubic millimeter provided net benefits over starting such therapy in patients after the CD4+, but the risks of unscheduled hospital admissions were similar in the two groups.
Journal ArticleDOI
Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy
Alison Rodger,Valentina Cambiano,Tina Bruun,Pietro Vernazza,Simon Collins,Jan van Lunzen,Giulio Maria Corbelli,Vicente Estrada,Anna Maria Geretti,Apostolos Beloukas,David Asboe,Pompeyo Viciana,Félix Gutiérrez,Bonaventura Clotet,Christian Pradier,Jan Gerstoft,Rainer Weber,Katarina Westling,Gilles Wandeler,Jan M. Prins,Armin Rieger,Marcel Stoeckle,Tim Kümmerle,Teresa Bini,Adriana Ammassari,Richard Gilson,Ivanka Krznaric,Matti Ristola,Robert Zangerle,Pia Handberg,Antonio Antela,Sris Allan,Andrew N. Phillips,Jens D Lundgren +33 more
TL;DR: Evaluating the rate of within-couple HIV transmission among serodifferent heterosexual and MSM couples during periods of sex without condoms and when the HIV-positive partner had HIV-1 RNA load less than 200 copies/mL found no phylogenetically linked transmissions.
Related Papers (5)
Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with Men
Robert M. Grant,Javier R. Lama,Peter L. Anderson,Vanessa McMahan,Albert Y. Liu,Lorena Vargas,Pedro Goicochea,Martin Casapia,Juan Vicente Guanira-Carranza,Maria Esther Ramirez-Cardich,Orlando Montoya-Herrera,Telmo Fernandez,Valdilea G. Veloso,Susan Buchbinder,Suwat Chariyalertsak,Mauro Schechter,Linda-Gail Bekker,Kenneth H. Mayer,Esper G. Kallas,K. Rivet Amico,Kathleen Mulligan,Lane R. Bushman,Robert J. Hance,Carmela Ganoza,Patricia Defechereux,Brian S. Postle,Furong Wang,J. Jeff McConnell,Jia-Hua Zheng,Jeanny Lee,James F. Rooney,Howard S. Jaffe,Ana Martinez,David N. Burns,David V. Glidden +34 more
Antiretroviral prophylaxis for HIV prevention in heterosexual men and women.
Jared M. Baeten,Deborah Donnell,Deborah Donnell,Patrick Ndase,Nelly Mugo,Nelly Mugo,James D. Campbell,Jonathan Wangisi,Jordan W. Tappero,Elizabeth A. Bukusi,Craig R. Cohen,Elly Katabira,Allan R. Ronald,Allan R. Ronald,Elioda Tumwesigye,Edwin Were,Kenneth H. Fife,James Kiarie,James Kiarie,Carey Farquhar,Grace John-Stewart,Aloysious Kakia,Josephine Odoyo,Akasiima Mucunguzi,Edith Nakku-Joloba,Rogers Twesigye,Kenneth Ngure,Cosmas Apaka,Harrison Tamooh,Fridah Gabona,Andrew Mujugira,Dana Panteleeff,Katherine K. Thomas,Lara Kidoguchi,Meighan Krows,Jennifer Revall,Susan Morrison,Harald S. Haugen,Mira Emmanuel-Ogier,Lisa Ondrejcek,Robert W. Coombs,Lisa M. Frenkel,Lisa M. Frenkel,Craig W. Hendrix,Namandjé N. Bumpus,David R. Bangsberg,Jessica E. Haberer,Wendy S. Stevens,Jairam R. Lingappa,Connie Celum +49 more