Journal ArticleDOI
Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria
Céline Candé,Isabelle Cohen,Eric Daugas,Luigi Ravagnan,Nathanael Larochette,Naoufal Zamzami,Guido Kroemer +6 more
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TLDR
Data suggest that AIF plays a role in the regulation of caspase-independent cell death, which is essential for programmed cell death during cavitation of embryoid bodies.About:
This article is published in Biochimie.The article was published on 2002-02-01. It has received 490 citations till now. The article focuses on the topics: Apoptosis-inducing factor & Programmed cell death.read more
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Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
TL;DR: A special focus is placed on the known roles of distinct mono- and poly-ADP-ribosylation reactions in physiological processes, such as mitosis, cellular differentiation and proliferation, telomere dynamics, and aging, as well as “programmed necrosis” and apoptosis.
Journal ArticleDOI
Molecular targets in cerebral ischemia for developing novel therapeutics.
TL;DR: The current status on the molecular mechanisms of stroke pathophysiology is covered with an endeavour to identify potential molecular targets such as targeting postsynaptic density-95 (PSD-95)/N-methyl-d-aspartate (NMDA) receptor interaction, certain key proteins involved in oxidative stress, CaMKs and MAPKs (ERK, p38 and JNK) signalling, inflammation and cell death pathways.
Journal ArticleDOI
VDAC, a multi-functional mitochondrial protein regulating cell life and death.
TL;DR: What is known about the VDAC channel in terms of its structure, relevance to ATP rationing, Ca(2+) homeostasis, protection against oxidative stress, regulation of apoptosis, involvement in several diseases and its role in the action of different drugs is reviewed.
Journal ArticleDOI
Apoptosis versus oncotic necrosis in hepatic ischemia/reperfusion injury.
TL;DR: Oncotic necrosis and apoptosis can share features and mechanisms, which sometimes makes discrimination between the 2 forms of cell death difficult, however, elucidation of critical cell death pathways under clinically relevant conditions will show potentially important therapeutic intervention strategies in hepatic ischemia/reperfusion injury.
Journal ArticleDOI
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases.
TL;DR: A special focus is placed on the proposed molecular mechanisms involved in these processes, such as signaling, regulation of telomere dynamics, remodeling of chromatin structure and transcriptional regulation, in the regulation of physiological and pathophysiological processes.
References
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Journal ArticleDOI
Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked
Jie Yang,Xuesong Liu,Xuesong Liu,Kapil N. Bhalla,Caryn Naekyung Kim,Ana Maria Ibrado,Jiyang Cai,Tsung I. Peng,Dean P. Jones,Xiaodong Wang,Xiaodong Wang +10 more
TL;DR: One possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria, which is normally located in the mitochondrial intermembrane space.
Journal ArticleDOI
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
TL;DR: In a cell-free apoptosis system, mitochondria spontaneously released cytochrome c, which activated DEVD-specific caspases, leading to fodrin cleavage and apoptotic nuclear morphology, and Bcl-2 acts to inhibit cy tochrome c translocation, thereby blocking caspase activation and the apoptotic process.
Journal ArticleDOI
Molecular characterization of mitochondrial apoptosis-inducing factor
Santos A. Susin,Hans K. Lorenzo,Naoufal Zamzami,Isabel Marzo,Bryan E. Snow,Joan Mangion,Etienne Jacotot,Paola Costantini,Markus Loeffler,Nathanael Larochette,David R. Goodlett,Ruedi Aebersold,David P. Siderovski,Josef M. Penninger,Guido Kroemer +14 more
TL;DR: The identification and cloning of an apoptosis-inducing factor, AIF, which is sufficient to induce apoptosis of isolated nuclei is reported, indicating that AIF is a mitochondrial effector of apoptotic cell death.
Journal ArticleDOI
Mitochondrial control of cell death
Guido Kroemer,John C. Reed +1 more
TL;DR: In many instances, permeabilization of mitochondrial membranes is a rate-limiting step of apoptotic or necrotic cell demise, which has important consequences for the pathophysiology of cell death, as well as for its pharmacological control.
Journal ArticleDOI
The proto-oncogene Bcl-2 and its role in regulating apoptosis
TL;DR: The mechanism of action of Bcl-2 provides clues for therapeutic interventions and could help in the development of new drugs to treat central nervous system disorders.
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