Journal ArticleDOI
Aspirin for treatment of lithium-associated sexual dysfunction in men: randomized double-blind placebo-controlled study.
Sepideh Saroukhani,Morteza Emami-Parsa,Amirhossein Modabbernia,Mandana Ashrafi,Mehdi Farokhnia,Reza Hajiaghaee,Shahin Akhondzadeh +6 more
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TLDR
The aim of the present study was to assess the effect of aspirin on lithium‐related sexual dysfunction in men with stable bipolar affective disorder (BAD).Abstract:
Objectives
The aim of the present study was to assess the effect of aspirin on lithium-related sexual dysfunction in men with stable bipolar affective disorder (BAD).
Methods
In a randomized, double-blind, placebo-controlled study, 32 men with stable BAD who had been on lithium maintenance therapy randomly received aspirin (240 mg/day) or placebo for six weeks. The International Index for Erectile Function (IIEF) was used to assess sexual symptoms at baseline, Week 3, and Week 6. Depressive and mania symptoms and plasma lithium concentrations were assessed at baseline and Week 6. Side effects were assessed using a checklist.
Results
Thirty patients (15/group) completed the study. Baseline and endpoint lithium concentrations and mania and depressive symptoms did not differ significantly between the two groups. Significant effects of time × treatment interaction were observed for total score [Greenhouse–Geisser: F(1.410,39.466) = 6.084, p = 0.010] and erectile function [Greenhouse–Geisser: F(1.629,45.602) = 7.250, p = 0.003]. By Week 6, patients in the aspirin group showed significantly greater improvement in the total (63.9% improvement from the baseline) and erectile function domain (85.4% improvement from the baseline) scores than the placebo group (14.4% and 19.7% improvement from the baseline, p-values = 0.002 and 0.001, respectively). By Week 6, 12 (80%) patients in the aspirin group and three (20%) patients in the placebo group met the criteria of minimal clinically important change [χ2(1) = 10.800, p = 0.001]. Other IIEF domains also showed significant improvement at the end of the trial. The frequency of side effects was similar between the two groups.
Conclusion
Aspirin effectively improves lithium-related sexual dysfunction in men with stable BAD.read more
Citations
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Journal ArticleDOI
Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder
Lakshmi N. Yatham,Sidney H. Kennedy,Sagar V. Parikh,Ayal Schaffer,David J. Bond,Benicio N. Frey,Verinder Sharma,Benjamin I. Goldstein,Soham Rej,Serge Beaulieu,Martin Alda,Glenda MacQueen,Roumen Milev,Arun V. Ravindran,Claire O'Donovan,Diane McIntosh,Raymond W. Lam,Gustavo Vazquez,Flávio Kapczinski,Roger S. McIntyre,Jan Marie Kozicky,Shigenobu Kanba,Beny Lafer,Trisha Suppes,Joseph R. Calabrese,Eduard Vieta,Gin S Malhi,Robert M. Post,Michael Berk +28 more
TL;DR: These 2018 CANMAT and ISBD Bipolar Treatment Guidelines represent the significant advances in the field since the last full edition was published in 2005, including updates to diagnosis and management as well as new research into pharmacological and psychological treatments.
Journal ArticleDOI
Lithium side effects and toxicity: prevalence and management strategies.
TL;DR: A simple set of management strategies that involve the timing of the lithium dose, minimizing lithium levels within the therapeutic range and, in some situations, the prescription of side effect antidotes will minimize the side effect burden for patients.
Journal ArticleDOI
Bipolar Disorder and Immune Dysfunction: Epidemiological Findings, Proposed Pathophysiology and Clinical Implications
TL;DR: The inflammatory-mood pathway presents several potential novel targets in the treatment of BD, and proof-of-concept clinical trials have shown a positive effect of anti-inflammatory agents in thetreatment of BD; however, further research is needed to determine the clinical utility of these treatments.
Journal ArticleDOI
Anti-inflammatory agents in the treatment of bipolar depression: a systematic review and meta-analysis.
Joshua D. Rosenblat,Ron Kakar,Ron Kakar,Michael Berk,Michael Berk,Lars Vedel Kessing,Maj Vinberg,Bernhard T. Baune,Rodrigo B. Mansur,Rodrigo B. Mansur,Elisa Brietzke,Benjamin I. Goldstein,Roger S. McIntyre +12 more
TL;DR: The objective of the current qualitative and quantitative review was to determine the overall antidepressant effect of adjunctive anti‐inflammatory agents in the treatment of bipolar depression.
Journal ArticleDOI
Bipolar Disorder and Inflammation.
TL;DR: Evidence from several clinical trials indicates that antiinflammatory agents may be incorporated into clinical practice soon, and further research is needed to establish the role of anti inflammatory agents in the treatment of bipolar disorder.
References
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Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
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A rating scale for mania: reliability, validity and sensitivity.
TL;DR: The MRS score correlated highly with an independent global rating, and with scores of two other mania rating scales administered concurrently, and also correlated with the number of days of subsequent stay in hospital.
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The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction
TL;DR: The IIEF addresses the relevant domains of male sexual function, is psychometrically sound, and has been linguistically validated in 10 languages and demonstrates the sensitivity and specificity for detecting treatment-related changes in patients with erectile dysfunction.
Journal ArticleDOI
Neural and developmental actions of lithium: A unifying hypothesis
TL;DR: Lithium, with an atomic weight of 6.9, is the smallest of the alkali metals, yet this simple ion can exert a profound effect on both human behavior and early embryonic devel- opment.
Journal ArticleDOI
Diagnostic evaluation of the erectile function domain of the International Index of Erectile Function.
TL;DR: The EF domain possesses favorable statistical properties as a diagnostic tool, not only in distinguishing between men with and without erectile dysfunction, but also in classifying levels of ED severity.
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