Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b.
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TLDR
A new gene function involved in the expression of mitochondrial cytochrome b is described, which is confirmed by analysis of the mitochondrial translation products in E158, a respiratory deficient strain of Saccharomyces cerevisiae with a recessive mutation in nuclear DNA.About:
This article is published in Journal of Biological Chemistry.The article was published on 1985-02-10 and is currently open access. It has received 396 citations till now. The article focuses on the topics: Cytochrome b & CYP2A13.read more
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Dystrophin: The protein product of the duchenne muscular dystrophy locus
TL;DR: The identification of the mdx mouse as an animal model for DMD has important implications with regard to the etiology of the lethal DMD phenotype, and the protein dystrophin is named because of its identification via the isolation of the Duchenne muscular dystrophy locus.
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Targeted mutation of the DNA methyltransferase gene results in embryonic lethality.
TL;DR: Results indicate that while a 3-fold reduction in levels of genomic m5C has no detectable effect on the viability or proliferation of ES cells in culture, a similar reduction of DNA methylation in embryos causes abnormal development and embryonic lethality.
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Biogenesis of Mitochondria
TL;DR: The MITOCHONDRIAL GENETIC SYSTEM, a chronology of key events and events leading to and after the invention of the mitochondria, is described.
Journal ArticleDOI
Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes
TL;DR: Codon usage in the highly expressed group shows a higher correlation with tRNA abundance, a greater degree of third base pyrimidine bias, and a lesser tendency to the A+T richness which is characteristic of the yeast genome.
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The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions
Daniel F. Woods,Peter J. Bryant +1 more
TL;DR: The results suggest that a signal transduction process involving guanine nucleotides occurs at the septate junction and is necessary for cell proliferation control in Drosophila epithelia.
References
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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal ArticleDOI
A new method for sequencing DNA
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: Reactions that cleave DNA preferentially at guanines, at adenines,At cytosines and thymines equally, and at cytosine alone are described.
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The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.
Jeffrey Vieira,Joachim Messing +1 more
TL;DR: A series of plasmid vectors containing the multiple cloning site (MCS7) of M13mp7 has been constructed and a kanamycin-resistance marker has been inserted into the center of the symmetrical MCS7 to yield a restriction-site-mobilizing element (RSM).
Book ChapterDOI
One-step gene disruption in yeast
TL;DR: The one-step gene disruption techniques described here are versatile in that a disruption can be made simply by the appropriate cloning experiment and the resultant chromosomal insertion is nonreverting and contains a genetically linked marker.
Journal ArticleDOI
Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes
TL;DR: This procedure allows detection of specific RNA bands with high sensitivity and low background by hybridization with 32P-labeled DNA probes followed by autoradiography.