Journal ArticleDOI
Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation
Barry M. Honda,Robert G. Roeder +1 more
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TLDR
It is reported that this protein factor is identical by immunological, chemical and functional criteria to the protein associated with 5S RNA as a 7S ribonucleoprotein (RNP) complex in immature oocytes.About:
This article is published in Cell.The article was published on 1980-11-01. It has received 203 citations till now. The article focuses on the topics: General transcription factor & RNA polymerase II.read more
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Journal ArticleDOI
Repetitive zinc‐binding domains in the protein transcription factor IIIA from Xenopus oocytes.
TL;DR: Analysis of the amino acid sequence reveals nine tandem similar units, each consisting of approximately 30 residues and containing two invariant pairs of cysteines and histidines, the most common ligands for zinc in the 7S particle of Xenopus laevis oocytes, which suggests that the protein contains repetitive zinc‐binding domains.
Book ChapterDOI
Eukaryotic gene transcription with purified components.
Journal ArticleDOI
The sex-determining region of the human Y chromosome encodes a finger protein
David C. Page,Rebecca Mosher,Elizabeth M. Simpson,Elizabeth M. C. Fisher,Graeme Mardon,Jonathan R. Pollack,Barbara McGillivray,Albert de la Chapelle,Laura G. Brown +8 more
TL;DR: The possibility that the Y-encoded finger protein is the testis-determining factor is discussed, and models of sex determination accommodating the finding of a related locus on the X chromosome are proposed.
Journal ArticleDOI
The protein product of the fragile X gene, FMR1, has characteristics of an RNA-binding protein.
TL;DR: It is found that FMR1 contains two types of sequence motifs recently found in RNA-binding proteins: an RGG box and two heterogeneous nuclear RNP K homology domains and the RNA binding activity of FMR 1 opens the way to understanding the function of F MR1.
Journal ArticleDOI
Mechanism of activation of early viral transcription by the adenovirus E1A gene product
TL;DR: It was found that early transcription could be detected in mutant-infected cells if the virus was added to cells in which protein synthesis was inhibited prior to infection, and it was proposed that the role of the E1A gene product in the activation of early viral transcription is to inactivate a cellular factor that prevents transcription from the early viral promoters.
References
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Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
The preparation of 131i-labelled human growth hormone of high specific radioactivity
TL;DR: The loss of immunological reactivity at high specific radioactivities or at high levels of chemical substitution with STAI/sup 127/!iodine is demonstrated.
Journal ArticleDOI
Enhanced autoradiographic detection of 32P and 125I using intensifying screens and hypersensitized film
TL;DR: This paper reports that autoradiographic sensitivity can be greatly increased for isotopes which emit y rays or high energy p particles by placing a pre-exposed film between the sample and a calcium tungstate X-ray intensifying screen and exposing at --70°C.
Journal ArticleDOI
Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure
TL;DR: A rapid and very sensitive method for detecting proteins as antigens after their separation in polyacrylamide/agarose composite gels, with or without sodium dodecyl sulfate.
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A specific transcription factor that can bind either the 5S RNA gene or 5S RNA.
Hugh R.B. Pelham,Donald D. Brown +1 more