Journal ArticleDOI
Astrocyte Control of Synaptic Transmission and Neurovascular Coupling
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TLDR
The application of subcellular imaging of Ca2+ signaling to astrocytes now provides functional data to support this structural notion that both excitatory and inhibitory signals provided by the same glial cell act in concert to regulate neuronal function.Abstract:
From a structural perspective, the predominant glial cell of the central nervous system, the astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the processes of ...read more
Citations
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Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
TL;DR: Preliminary data from patients with inflammatory disorders, as well as medically healthy depressed patients, suggest that inhibiting proinflammatory cytokines or their signaling pathways may improve depressed mood and increase treatment response to conventional antidepressant medication.
Journal ArticleDOI
Gliotransmitters Travel in Time and Space
Alfonso Araque,Giorgio Carmignoto,Philip G. Haydon,Stéphane H. R. Oliet,Richard Robitaille,Andrea Volterra +5 more
TL;DR: It is proposed that astrocytes mainly signal through high-affinity slowly desensitizing receptors to modulate neurons and perform integration in spatiotemporal domains complementary to those of neurons.
Journal ArticleDOI
Immune System to Brain Signaling: Neuropsychopharmacological Implications
Lucile Capuron,Andrew H. Miller +1 more
TL;DR: The elucidation of the mechanisms by which the immune system influences behavior yields a host of targets for potential therapeutic development as well as informing strategies for the prevention of neuropsychiatric disease in at risk populations.
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Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders
TL;DR: There is growing evidence that the glutamatergic system is central to the neurobiology and treatment of mood disorders and exciting new prospects for the development of improved therapeutics for these devastating disorders are discussed.
Journal ArticleDOI
Astrocytes control breathing through pH-dependent release of ATP
Alexander V. Gourine,Vitaliy Kasymov,Nephtali Marina,Feige Tang,M Figueiredo,S Lane,Anja G. Teschemacher,K. Michael Spyer,Karl Deisseroth,Sergey Kasparov +9 more
TL;DR: It is found that astrocytes of the brainstem chemoreceptor areas are highly chemosensitive and responded to physiological decreases in pH with vigorous elevations in intracellular Ca2+ and release of adenosine triphosphate (ATP) and induced adaptive increases in breathing.
References
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Journal ArticleDOI
Developmental and regional expression in the rat brain and functional properties of four NMDA receptors.
TL;DR: Recombinant binary NR1-NR2 channels show comparable Ca2+ permeabilities, but marked differences in voltage-dependent Mg2+ block and in offset decay time constants, which provide a basis for NMDA channel heterogeneity in the brain.
Journal ArticleDOI
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization
TL;DR: It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Journal ArticleDOI
The role of glutamate neurotoxicity in hypoxic- ischemic neuronal death
Dennis W. Choi,Steven M. Rothman +1 more
TL;DR: A critical question has been why brain, more than mostother tissues, is so vulnerable to hypoxic-ischemic insults, and at least some of this special vulnerability may be accounted for by the central neurotoxicity of the endogenous excitatory
Journal ArticleDOI
Tripartite synapses : Glia, the unacknowledged partner
TL;DR: It is suggested that perisynaptic Schwann cells and synaptically associated astrocytes should be viewed as integral modulatory elements of tripartite synapses.
Journal ArticleDOI
Neurovascular regulation in the normal brain and in Alzheimer's disease.
TL;DR: The emerging view is that cerebroVascular dysregulation is a feature not only of cerebrovascular pathologies, such as stroke, but also of neurodegenerative conditions, suchas Alzheimer's disease.
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