Journal ArticleDOI
Autoantibodies in chronic inflammatory neuropathies: diagnostic and therapeutic implications
TLDR
Observations provide proof of concept that identifying the target antigens in tissue-specific antibody-mediated autoimmune diseases is important, not only to understand their underlying pathogenic mechanisms, but also to correctly diagnose and treat affected patients.Abstract:
The chronic inflammatory neuropathies (CINs) are rare, very disabling autoimmune disorders that generally respond well to immune therapies such as intravenous immunoglobulin (IVIg). The most common forms of CIN are chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy, and polyneuropathy associated with monoclonal gammopathy of unknown significance. The field of CIN has undergone a major advance with the identification of IgG4 autoantibodies directed against paranodal proteins in patients with CIDP. Although these autoantibodies are only found in a small subset of patients with CIDP, they can be used to guide therapeutic decision-making, as these patients have a poor response to IVIg. These observations provide proof of concept that identifying the target antigens in tissue-specific antibody-mediated autoimmune diseases is important, not only to understand their underlying pathogenic mechanisms, but also to correctly diagnose and treat affected patients. This state-of-the-art Review focuses on the role of autoantibodies against nodes of Ranvier in CIDP, a clinically relevant emerging field of research. The role of autoantibodies in other immune-mediated neuropathies, including other forms of CIN, primary autoimmune neuropathies, neoplasms, and systemic diseases that resemble CIN, are also discussed.read more
Citations
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Journal Article
Antibodies to Contactin-1 in Chronic Inflammatory Demyelinating Polyneuropathy (P01.150)
TL;DR: I Illa et al. as mentioned in this paper designed an unbiased approach for antigen unraveling using patients9 sera for hippocampal neuron immunoprecipitation, which revealed the presence of antibodies against CNTN1 complex proteins in a small subset of CIDP patients sharing specific clinical features.
Journal Article
The Clinical Spectrum of Caspr2-Antibody Associated Disease (S12.008)
Agnes van Sonderen,Helena Ariño,Mar Petit-Pedrol,Frank Leypoldt,Peter Körtvelyessy,Eric Lancaster,Paul W. Wirtz,Marco W.J. Schreurs,Peter A. E. Sillevis Smitt,Francesc Graus,Josep Dalmau,Maarten J. Titulaer +11 more
TL;DR: In this paper, the authors describe a large cohort of contactin-associated protein 2 (Caspr2) patients with this disorder and provide a framework for patient recognition, which is important because it is treatable.
Journal ArticleDOI
Complement in neurological disorders and emerging complement-targeted therapeutics
TL;DR: The complement system, the role it plays in autoimmune neurological disease and neurodegenerative disease, and an overview of the latest therapeutics that target complement and that can be used for or have potential in neurological disorders are discussed.
Journal ArticleDOI
Progress in diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy.
TL;DR: Patients who do not improve, or insufficiently improve after treatment, might have specific characteristics related to a distinct disease mechanism caused by immunoglobulin G4 antibodies to nodal or paranodal proteins, and could require alternative treatments.
Journal ArticleDOI
European Academy of Neurology/Peripheral Nerve Society guideline on diagnosis and treatment of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint Task Force-Second revision.
Peter Van den Bergh,Pieter A. van Doorn,Robert D M Hadden,Bert Avau,Patrik Vankrunkelsven,Jeffrey A. Allen,Shahram Attarian,Patricia H. Blomkwist-Markens,David R. Cornblath,Filip Eftimov,H. Stephan Goedee,Thomas Harbo,Satoshi Kuwabara,Richard A. Lewis,Michael P. Lunn,Eduardo Nobile-Orazio,Luis Querol,Yusuf A. Rajabally,Claudia Sommer,Haluk Topaloglu +19 more
TL;DR: The 2010 consensus guideline on chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) was revised in this article, with a focus on the diagnosis and treatment of CIDP.
References
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TL;DR: Few review types possess prescribed and explicit methodologies and many fall short of being mutually exclusive, but this typology provides a valuable reference point for those commissioning, conducting, supporting or interpreting reviews, both within health information and the wider health care domain.
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Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
Journal ArticleDOI
European Federation of Neurological Societies/Peripheral Nerve Society Guideline on Management of Chronic Inflammatory Demyelinating Polyradiculoneuropathy: Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society - First Revision
P. Van den Bergh,R. D. M. Hadden,Pierre Bouche,David R. Cornblath,A. Hahn,Isabel Illa,Carol L. Koski,J. M. Léger,Eduardo Nobile-Orazio,John D. Pollard,Claudia Sommer,P.A. van Doorn,I. N. van Schaik +12 more
TL;DR: The Task Force agreed on Good Practice Points to define clinical and electrophysiological diagnostic criteria for CIDP with or without concomitant diseases and investigations to be considered.
Journal ArticleDOI
Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange
Marijn Van Der Neut Kolfschoten,Janine Schuurman,Mario Losen,Wim K. Bleeker,Pilar Martinez-Martinez,Ellen Vermeulen,Tamara H. den Bleker,Luus Wiegman,Tom Vink,Lucien A. Aarden,Marc H. De Baets,Marc H. De Baets,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Rob C. Aalberse,Paul W. H. I. Parren +15 more
TL;DR: IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies.