Journal ArticleDOI
Biocompatibility and drug delivery systems
Daniel S. Kohane,Robert Langer +1 more
TLDR
Biocompatibility is discussed, specifically as it relates to drug delivery systems, which differ from other biomaterial-based devices by possibly containing large quantities of drugs with their own effects on tissues.Abstract:
Drug delivery technology has emerged as an important focus of biotechnological research and commercial enterprise. While much attention is justifiably focused on the design and effectiveness of drug delivery devices, the nature of their interaction with surrounding tissues – their biocompatibility – is crucial. Here we discuss biocompatibility, specifically as it relates to drug delivery systems, which differ from other biomaterial-based devices by possibly containing large quantities of drugs with their own effects on tissues.read more
Citations
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Engineered Nanoparticles for Drug Delivery in Cancer Therapy
TL;DR: It is anticipated that precisely engineered nanoparticles will emerge as the next-generation platform for cancer therapy and many other biomedical applications.
Journal ArticleDOI
Molecularly Engineered Dual-Crosslinked Hydrogel with Ultrahigh Mechanical Strength, Toughness, and Good Self-Recovery
TL;DR: A molecularly engineered dual-crosslinked hydrogel with extraordinary mechanical properties is reported, formed with both chemical crosslinking and acrylic-Fe(III) coordination; these impart the elasticity and enhance the mechanical properties by effectively dissipating energy.
Journal ArticleDOI
Materials design for bone-tissue engineering
TL;DR: In this paper, the authors provide an overview of materials-design considerations for bone-tissue-engineering applications in both disease modelling and treatment of injuries and disease in humans, and highlight scalable technologies that can fabricate natural and synthetic biomaterials (polymers, bioceramics, metals and composites) into forms suitable for bone tissue engineering applications in human therapies and disease models.
Journal ArticleDOI
Biocompatibility of engineered nanoparticles for drug delivery.
Sheva Naahidi,Mousa Jafari,Faramarz Edalat,Faramarz Edalat,Kevin Raymond,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini,Pu Chen +8 more
TL;DR: The data existing in the literature regarding biocompatibility of nanoparticles for drug delivery applications is discussed, and the various types of nanoparticle used in drug delivery systems are reviewed while addressing new challenges and research directions.
Journal ArticleDOI
Biocompatibility of hydrogel-based scaffolds for tissue engineering applications
Sheva Naahidi,Mousa Jafari,Megan Logan,Yujie Wang,Yongfang Yuan,Hojae Bae,Brian Dixon,Pu Chen +7 more
TL;DR: This review will aid in the improvement of design of non-invasive, smart hydrogels that can be utilized for tissue engineering and other biomedical applications and a future outlook of the field of biocompatibility within the context of hydrogel-based scaffolds is concluded.
References
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Journal ArticleDOI
Fabrication of novel biomaterials through molecular self-assembly.
TL;DR: Two complementary strategies can be used in the fabrication of molecular biomaterials as discussed by the authors : chemical complementarity and structural compatibility, both of which confer the weak and noncovalent interactions that bind building blocks together during self-assembly.
Journal ArticleDOI
On the mechanisms of biocompatibility.
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
Journal ArticleDOI
Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
Gabriel A. Silva,Gabriel A. Silva,Catherine Czeisler,Krista L. Niece,Elia Beniash,Daniel A. Harrington,John A. Kessler,Samuel I. Stupp +7 more
TL;DR: The artificial nanofiber scaffold induced very rapid differentiation of cells into neurons, while discouraging the development of astrocytes, linked to the amplification of bioactive epitope presentation to cells by the nanofibers.
Journal ArticleDOI
New challenges in biomaterials
Nicholas A. Peppas,Robert Langer +1 more
TL;DR: Approaches for controlling the interface between tissue and biomaterials and ways in which the engineered materials may contribute to medicine are considered.
Journal ArticleDOI
Nanostructured materials for applications in drug delivery and tissue engineering
TL;DR: The biological functions of encapsulated drugs and cells can be dramatically enhanced by designing biomaterials with controlled organizations at the nanometer scale.
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