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Open AccessJournal ArticleDOI

Biodegradable calcium phosphate nanoparticle with lipid coating for systemic siRNA delivery.

Jun Li, +4 more
- 19 Mar 2010 - 
- Vol. 142, Iss: 3, pp 416-421
TLDR
The new formulation of lipid coated calcium phosphate nanoparticle (NP) improved the in vitro silencing effect 3-4 folds compared to the previous LPD formulation, but had a negligible immunotoxicity.
About: 
This article is published in Journal of Controlled Release.The article was published on 2010-03-19 and is currently open access. It has received 416 citations till now. The article focuses on the topics: Small interfering RNA & Cationic liposome.

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Citations
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Nanomaterials for theranostics: recent advances and future challenges.

Eun Kyung Lim, +7 more
- 14 Jan 2015 - 
TL;DR: Challenges Eun-Kyung Lim,†,‡,§ Taekhoon Kim, Soonmyung Paik, Seungjoo Haam, Yong-Min Huh,*,† and Kwangyeol Lee
Journal ArticleDOI

RNA-based therapeutics: current progress and future prospects.

John C. Burnett, +1 more
- 27 Jan 2012 - 
TL;DR: Promising results from recent clinical trials suggest that barriers to clinical progress of RNA-based drugs may be overcome with improved synthetic delivery carriers and chemical modifications of the RNA therapeutics.
Journal ArticleDOI

Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment

Yunlu Dai, +4 more
- 19 Jun 2017 - 
TL;DR: This review article summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones, which it believes offer a good chance for the practical translation of nanoparticle formulas into clinic.
Journal ArticleDOI

Recent advances in nonviral vectors for gene delivery

Xia Guo, +1 more
- 17 Jul 2012 - 
TL;DR: Novel nonviral vectors based on nucleic acids, typically based on cationic lipids or polymers, are classified as multifunctional hybrid nucleic acid vectors, novel membrane/core nanoparticles for nucleicacid delivery, and ultrasound-responsive nucleic Acid vectors.
Journal ArticleDOI

Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.

Jonas G. Croissant, +2 more
- 01 Mar 2017 - 
TL;DR: The degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanommaterial in this large family according to the targeted applications and the required clearance kinetics.
References
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Journal ArticleDOI

A new technique for the assay of infectivity of human adenovirus 5 DNA.

Frank L. Graham, +1 more
- 01 Apr 1973 - 
TL;DR: A new technique for assaying infectivity of adenovirus 5 DNA has been developed and a reproducible relationship between amounts of DNA inoculated per culture and numbers of plaques produced was demonstrated.
Journal ArticleDOI

Recent advances with liposomes as pharmaceutical carriers.

Vladimir P. Torchilin
- 01 Feb 2005 - 
TL;DR: For further successful development of this field, promising trends must be identified and exploited, albeit with a clear understanding of the limitations of these approaches.
Journal ArticleDOI

Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells

Viktoriya Sokolova, +1 more
- 08 Feb 2008 - 
TL;DR: The current state of the art of transfection of nucleic acids into living cells is discussed from a chemical viewpoint and advantages and disadvantages of the available methods are compared.
Journal ArticleDOI

On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids.

Ismail M. Hafez, +2 more
- 01 Aug 2001 - 
TL;DR: It is suggested that the ability of cationic lipids to promote nonbilayer structures in combination with anionic phospholipids leads to disruption of the endosomal membrane following uptake of nucleic acid–cationic lipid complexes into cells, thus facilitating cytoplasmic release of the plasmid or oligonucleotide.
Journal ArticleDOI

Enhancing polyethylenimine's delivery of plasmid DNA into mammalian cells

Mini Thomas, +1 more
- 12 Nov 2002 - 
TL;DR: Dodecylation of primary amino groups of 2-kDa PEI yields a nontoxic polycation whose transfection efficiency in the presence of serum is 400 times higher than the parent's and which exceeds 5-fold even that of PEI25.
Related Papers (5)

Knocking down barriers: advances in siRNA delivery

Kathryn A. Whitehead, +2 more
- 01 Feb 2009 - 

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

Andrew Fire, +6 more
- 19 Feb 1998 - 

Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles

Mark E. Davis, +9 more
- 15 Apr 2010 - 

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, +40 more
- 01 Feb 2010 - 

A new technique for the assay of infectivity of human adenovirus 5 DNA.

Frank L. Graham, +1 more
- 01 Apr 1973 - 
Frequently Asked Questions (1)
Q1. What have the authors contributed in "Biodegradable calcium phosphate nanoparticle with lipid coating for systemic sirna delivery" ?

Based on the previous formulation, liposome-polycation-DNA ( LPD ), which was DNA-protamine complex wrapped by cationic liposome followed by post-insertion of PEG, LCP was similar to LPD NP except that the core was replaced by a biodegradable nano-sized calciumphosphate precipitate prepared by using water-in-oil micro-emulsions in which siRNA was entrapped. The LCP NP was further modified by post-insertion of polyethylene glycol ( PEG ) with or without anisamide, a sigma-1 receptor ligand for systemic administration.