Nanoparticle design strategies for enhanced anticancer therapy by exploiting the tumour microenvironment
TLDR
This review article summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones, which it believes offer a good chance for the practical translation of nanoparticle formulas into clinic.Abstract:
Nanovehicles can efficiently carry and deliver anticancer agents to tumour sites Compared with normal tissue, the tumour microenvironment has some unique properties, such as vascular abnormalities, hypoxia and acidic pH There are many types of cells, including tumour cells, macrophages, immune and fibroblast cells, fed by defective blood vessels in the solid tumour Exploiting the tumour microenvironment can benefit the design of nanoparticles for enhanced therapeutic effectiveness In this review article, we summarized the recent progress in various nanoformulations for cancer therapy, with a special emphasis on tumour microenvironment stimuli-responsive ones Numerous tumour microenvironment modulation strategies with promising cancer therapeutic efficacy have also been highlighted Future challenges and opportunities of design consideration are also discussed in detail We believe that these tumour microenvironment modulation strategies offer a good chance for the practical translation of nanoparticle formulas into clinicread more
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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation
Jingchao Li,Kanyi Pu +1 more
TL;DR: This review summarizes the recent progress in the development of OSMs based on small-molecule fluorophores, aggregation-induced emission (AIE) dyes and semiconducting oligomer/polymer nanoparticles (SONs/SPNs) for advanced biophotonic applications and highlights OSMs as a multifunctional platform for a wide range of biomedical applications.
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Recent Progress in Ferroptosis Inducers for Cancer Therapy
TL;DR: A literature review of ferroptosis inducers (including small molecules and nanomaterials) is presented to delineate their design, action mechanisms, and anticancer applications.
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Biodegradable Biomimic Copper/Manganese Silicate Nanospheres for Chemodynamic/Photodynamic Synergistic Therapy with Simultaneous Glutathione Depletion and Hypoxia Relief.
Conghui Liu,Dongdong Wang,Shuyuan Zhang,Yaru Cheng,Fan Yang,Yi Xing,Tailin Xu,Haifeng Dong,Xueji Zhang +8 more
TL;DR: In this paper, a biodegradable cancer cell membrane-coated mesoporous copper/manganese silicate nanospheres (mCMSNs) with homotypic targeting ability to the cancer cell lines and enhanced ROS generation through singlet oxygen (1O2) production and glutathione (GSH)-activated Fenton reaction, showing excellent CDT/PDT synergistic therapeutic effects.
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Dual-Peak Absorbing Semiconducting Copolymer Nanoparticles for First and Second Near-Infrared Window Photothermal Therapy: A Comparative Study.
TL;DR: The development of the first organic photothermal nanoagent (SPNI‐II) with dual‐peak absorption in both NIR windows and its utilization in photothermal therapy (PTT) are reported herein.
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A Magnetofluorescent Carbon Dot Assembly as an Acidic H 2 O 2 -Driven Oxygenerator to Regulate Tumor Hypoxia for Simultaneous Bimodal Imaging and Enhanced Photodynamic Therapy
Qingyan Jia,Jiechao Ge,Weimin Liu,Xiuli Zheng,Shiqing Chen,Yongmei Wen,Hongyan Zhang,Pengfei Wang +7 more
TL;DR: The collective properties of the Mn‐CD assembly enable it to be utilized as an acidic H2O2‐driven oxygenerator to increase the oxygen concentration in hypoxic solid tumors for simultaneous bimodal FL/MR imaging and enhanced PDT.
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Integrins: versatility, modulation, and signaling in cell adhesion.
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Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome
Jérôme Galon,Anne Costes,Fátima Sánchez-Cabo,Amos Kirilovsky,Bernhard Mlecnik,Christine Lagorce-Pagès,Marie Tosolini,Matthieu Camus,Anne Berger,Philippe Wind,Franck Zinzindohoué,Patrick Bruneval,Paul-Henri Cugnenc,Zlatko Trajanoski,Wolf H. Fridman,Franck Pagès +15 more
TL;DR: In situ analysis of tumor-infiltrating immune cells may be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.
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Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
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