Biopharmaceutical benchmarks 2018.
TLDR
The market for monoclonal antibodies continues to reign supreme, although cellular and gene therapies are slowly starting to gather momentum, andgeoning growth in biosimilars may threaten future brand monopolies.Abstract:
Monoclonal antibodies (mAbs) continue to reign supreme, although cellular and gene therapies are slowly starting to gather momentum. Burgeoning growth in biosimilars may threaten future brand monopolies for mAbs and other biologics.read more
Citations
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Recent Developments in Bioprocessing of Recombinant Proteins: Expression Hosts and Process Development.
TL;DR: Recently, advances have been made in the various areas of bioprocessing and are being utilized to develop effective processes for producing recombinant proteins that can be used as therapeutics, vaccines, and diagnostic reagents.
Journal ArticleDOI
Critical Analysis of the Commercial Potential of Plants for the Production of Recombinant Proteins.
TL;DR: The strengths of plant expression systems for specific applications are discussed, but the bottlenecks that must be overcome before plants can compete with conventional systems are addressed, enabling the future commercial utilization of plants for the production of valuable proteins.
Journal ArticleDOI
Phage Display Derived Monoclonal Antibodies: From Bench to Bedside.
Mohamed A. Alfaleh,Hashem O. Alsaab,Ahmad Bakur Mahmoud,Almohanad A. Alkayyal,Martina L. Jones,Stephen M. Mahler,Anwar M. Hashem +6 more
TL;DR: The utility of phage display as a powerful platform for therapeutic antibodies discovery is illustrated and all the approved mAbs derived fromphage display are described.
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High-Resolution Native Mass Spectrometry.
TL;DR: A review of recent developments in high-resolution native mass spectrometer applications can be found in this article, which describes applications in the structural analysis of protein assemblies, proteoform profiling of biopharmaceuticals and plasma proteins.
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Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment.
TL;DR: This review study study MOFs-based biomineralization for cancer treatment and summarize the unique properties of MOF hybrids, which likely opens new research orientations for cancer theranostics.
References
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CAR T cell immunotherapy for human cancer
TL;DR: Opportunities and challenges for entering mainstream oncology that presently face the CAR T field are described, with a focus on the challenges that have emerged over the past several years.
Journal ArticleDOI
Biopharmaceutical benchmarks 2014
TL;DR: Monoclonal antibodies continue their march on the markets, and optimized so-called biobetter versions of existing biologics are also gaining ground, but the rate of biosimilar approvals has seen a dramatic slowdown in recent years.
Journal ArticleDOI
Biopharmaceutical benchmarks 2010
TL;DR: Over the past four years, several new types of experimental biologic treatment have received commercial registration, but the emergence of biosimilars represents the biggest shift in the biologic approval landscape.
Journal ArticleDOI
Gene therapy clinical trials worldwide to 2017: An update
Samantha L. Ginn,Anais K. Amaya,Ian E. Alexander,Ian E. Alexander,Michael Edelstein,Mohammad R. Abedi +5 more
TL;DR: This review presents the analysis of clinical trials that, to the best of the knowledge, have been or are being performed worldwide, and discusses key trends since the previous review, namely the use of chimeric antigen receptor T cells for the treatment of cancer and advancements in genome editing technologies.
Journal ArticleDOI
Biopharmaceutical benchmarks 2006
TL;DR: The rate of biopharmaceutical approvals has leveled off, but some milestones bode well for the future.
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