Blinatumomab versus Chemotherapy for Advanced Acute Lymphoblastic Leukemia
Hagop M. Kantarjian,Anthony S. Stein,Nicola Gökbuget,Adele K. Fielding,Andre C. Schuh,Josep-Maria Ribera,Andrew H. Wei,Hervé Dombret,Robin Foà,Renato Bassan,Onder Arslan,Miguel A. Sanz,Julie Bergeron,Fatih Demirkan,Ewa Lech-Maranda,Alessandro Rambaldi,Xavier Thomas,Heinz-August Horst,Monika Brüggemann,Wolfram Klapper,Brent L. Wood,Alex Fleishman,Dirk Nagorsen,Chris Holland,Zachary Zimmerman,Max S. Topp +25 more
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TLDR
Treatment with blinatumomab resulted in significantly longer overall survival than chemotherapy among adult patients with relapsed or refractory B‐cell precursor ALL, and remission rates within 12 weeks after treatment initiation were significantly higher.Abstract:
BackgroundBlinatumomab, a bispecific monoclonal antibody construct that enables CD3-positive T cells to recognize and eliminate CD19-positive acute lymphoblastic leukemia (ALL) blasts, was approved for use in patients with relapsed or refractory B-cell precursor ALL on the basis of single-group trials that showed efficacy and manageable toxic effects. MethodsIn this multi-institutional phase 3 trial, we randomly assigned adults with heavily pretreated B-cell precursor ALL, in a 2:1 ratio, to receive either blinatumomab or standard-of-care chemotherapy. The primary end point was overall survival. ResultsOf the 405 patients who were randomly assigned to receive blinatumomab (271 patients) or chemotherapy (134 patients), 376 patients received at least one dose. Overall survival was significantly longer in the blinatumomab group than in the chemotherapy group. The median overall survival was 7.7 months in the blinatumomab group and 4.0 months in the chemotherapy group (hazard ratio for death with blinatumomab...read more
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Allogeneic stem-cell transplantation with sequential conditioning in adult patients with refractory or relapsed acute lymphoblastic leukemia: a report from the EBMT Acute Leukemia Working Party
Abdul Hamid Bazarbachi,Rama Al Hamed,Myriam Labopin,Boris V. Afanasyev,Rose Marie Hamladji,Dietrich W. Beelen,Matthias Eder,Christof Scheid,Depei Wu,Donald Bunjes,Polina Stepensky,Johanna Tischer,Nicolaus Kröger,Zina Peric,Mahmoud Aljurf,Sebastian Giebel,Arnon Nagler,Mohamad Mohty +17 more
TL;DR: Patients with RR-T-cell ALL still face extremely poor outcomes, highlighting the importance of incorporating novel therapies, for which TBI-based sequential conditioning could be one of few available options.
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Current challenges and opportunities in treating adult patients with Philadelphia-negative acute lymphoblastic leukaemia.
TL;DR: The aim of this review is to consolidate the abundance of emerging data and to review and revisit the concepts of risk‐stratification, choice of induction and post‐remission strategies as well as to discuss and update the approach to specific populations with ALL, such as young adult, elderly/unfit and relapsed/refractory patients with ALL.
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Concomitant use of blinatumomab and donor lymphocyte infusion for mixed-phenotype acute leukemia: a case report with literature review
Seren Durer,Ceren Durer,Madeeha Shafqat,Isin Y Comba,Saad Ullah Malik,Warda Faridi,Shehroz Aslam,Awais Ijaz,Muhammad Junaid Tariq,Muhammad Asad Fraz,Muhammad Usman,Ali Younas Khan,Ali McBride,Faiz Anwer +13 more
TL;DR: A 51-year-old female with mixed phenotype acute leukemia who had a hematologic relapse 3 months after she received total body irradiation-based myeloablative allogeneic hematopoietic stem cell transplantation from an unrelated human leukocyte antigen matched (10/10) donor achieves complete remission with minimal residual disease negativity using the combination of blinatumomab and DLI.
Journal ArticleDOI
Immunotherapy in pediatric B-cell acute lymphoblastic leukemia.
Kirk D. Wyatt,Richard J. Bram +1 more
TL;DR: The role of the human immune system in the development and treatment of childhood ALL is reviewed and an overview of current and upcoming immunotherapeutic treatment approaches is provided.
Journal ArticleDOI
Long-term follow-up of salvage therapy using a combination of inotuzumab ozogamicin and mini-hyper-CVD with or without blinatumomab in relapsed/refractory Philadelphia chromosome-negative acute lymphoblastic leukemia.
Elias Jabbour,Koji Sasaki,Nicholas J. Short,Farhad Ravandi,Xuelin Huang,Joseph D. Khoury,Rashmi Kanagal-Shamanna,Jeffrey L. Jorgensen,Issa F. Khouri,Partow Kebriaei,Nitin Jain,Yesid Alvarado,Tapan M. Kadia,Shilpa Paul,Guillermo Garcia-Manero,Bouthaina S. Dabaja,Jan A. Burger,Courtney D. DiNardo,Naval A. Daver,Guillermo Montalban-Bravo,Musa Yilmaz,Maro Ohanian,Alessandra Ferrajoli,Jovitta Jacob,Meagan Rostykus,Rebecca Garris,Susan O'Brien,Hagop M. Kantarjian +27 more
TL;DR: The sequential addition of blinatumomab might improve outcome in patients with R/R ALL and the combination of inotuzumab with low‐intensity mini–hyper‐CVD has shown encouraging results.
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