Blood Coagulation, Inflammation, and Malaria
TLDR
The Tissue Factor Model (TFM) for malaria pathogenesis is presented, which places TF as the interface between sequestration, endothelial cell (EC) activation, blood coagulation disorder, and inflammation often associated with the disease.Abstract:
Malaria remains a highly prevalent disease in more than 90 countries and accounts for at least 1 million deaths every year. Plasmodium falciparum infection is often associated with a procoagulant t...read more
Citations
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Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
Bruno B. Andrade,Bruno B. Andrade,Antonio Reis-Filho,Antonio Reis-Filho,Sebastião M. Souza-Neto,Sebastião M. Souza-Neto,Jorge Clarêncio,Jorge Clarêncio,Luís Marcelo Aranha Camargo,Aldina Barral,Aldina Barral,Manoel Barral-Netto,Manoel Barral-Netto +12 more
TL;DR: Different clinical presentations of vivax malaria infection present strong association with activation of pro-inflammatory responses and cytokine imbalance, which is of utmost importance to improve current knowledge about physiopathological concepts of this serious widespread disease.
Journal ArticleDOI
Malaria's deadly grip: cytoadhesion of Plasmodium falciparum-infected erythrocytes.
Joseph D. Smith,Joseph D. Smith,J. Alexandra Rowe,Matthew K. Higgins,Thomas Lavstsen,Thomas Lavstsen +5 more
TL;DR: Recent findings on the origins and evolution of the var gene family, the structure–function of Pf EMP1 proteins, and a distinct subset of PfEMP1 variants that have been associated with severe childhood malaria are discussed.
Journal ArticleDOI
Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria
Adéla Nacer,Alexandru Movila,Kerstin Baer,Sebastian A. Mikolajczak,Stefan H. I. Kappe,Ute Frevert +5 more
TL;DR: It appears that neurological signs and coma in ECM are due to regulated opening of paracellular-junctional and transcellular-vesicular fluid transport pathways at the neuroimmunological BBB, and blocking of LFA-1 mediated cellular interactions prevented leukocyte adhesion, vascular leakage, neurological signs, and death from ECM.
Journal ArticleDOI
Investigating the Pathogenesis of Severe Malaria: A Multidisciplinary and Cross-Geographical Approach
Samuel C. Wassmer,Terrie E. Taylor,Pradipsinh K. Rathod,Saroj K. Mishra,Sanjib Mohanty,Myriam Arévalo-Herrera,Manoj T. Duraisingh,Joseph D. Smith +7 more
TL;DR: This review highlights progress and outstanding questions in severe malaria pathophysiology and summarizes key areas of pathogenesis research within the International Centers of Excellence for Malaria Research program.
Journal ArticleDOI
Management of imported malaria in Europe
Helena H. Askling,Helena H. Askling,Fabrice Bruneel,Gerd D. Burchard,Francesco Castelli,Peter L. Chiodini,Martin P. Grobusch,Rogelio López-Vélez,Margaret Paul,Eskild Petersen,Corneliu Petru Popescu,Michael Ramharter,Patricia Schlagenhauf +12 more
TL;DR: In this position paper, the European Society for Clinical Microbiology and Infectious Diseases, Study Group on Clinical Parasitology, summarizes main issues regarding the management of imported malaria cases.
References
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