Journal ArticleDOI
Breast cancer cell-derived fibroblast growth factor 2 and vascular endothelial growth factor are chemoattractants for bone marrow stromal stem cells.
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It is demonstrated that VEGF and FGF2 induce migration of MSCs are secreted by breast cancer cells, their receptors are present on M SCs, and depletion of these growth factors reduces migration, and are therefore 2 relevant growth factors for MSC migration toward breast cancer Cells.Abstract:
Objective:Recent efforts by the scientific community to characterize the complex interplay between different cell types involved in the development of tumors have led us to investigate the roles of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF2) in the development ofread more
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Human Bone Marrow and Adipose Tissue Mesenchymal Stem Cells: A User's Guide
TL;DR: This review tries to provide a detailed technical overview of the methods used for human bone-marrow (BM)derived and adipose-tissue (AT)-derived MSC isolation, in vitro expansion, and characterization for tissue repair.
Journal ArticleDOI
Mesenchymal stem cells in tumor development: Emerging roles and concepts
TL;DR: Current knowledge about the involvement of MSCs in cancer pathogenesis is summarized and accumulating evidence that have placed them at the center of the pro-malignant tumor stroma is reviewed.
Journal ArticleDOI
Double-edged sword of mesenchymal stem cells: Cancer-promoting versus therapeutic potential.
Hwa-Yong Lee,In-Sun Hong +1 more
TL;DR: A number of findings are summarized to provide current information about the therapeutic potential of MSCs in various diseases and the potential roles of M SCs in tumor progression.
Journal ArticleDOI
Sequential expression of putative stem cell markers in gastric carcinogenesis
Tao Wang,Chee Wee Ong,J. Shi,Supriya Srivastava,Benedict Yan,Chee Leong Cheng,Wei Peng Yong,Shing Leng Chan,Khay Guan Yeoh,Barry Iacopetta,Manuel Salto-Tellez +10 more
TL;DR: CD44 and Musashi-1 are frequently expressed in both premalignant gastric lesions and invasive GC, whereas CD133 expression is restricted mainly to neoplastic tissues.
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Effects of human mesenchymal stem cells on ER-positive human breast carcinoma cells mediated through ER-SDF-1/CXCR4 crosstalk.
Lyndsay V. Rhodes,James W. Antoon,Shannon E. Muir,Steven Elliott,Barbara S. Beckman,Matthew E. Burow +5 more
TL;DR: The effects of hMSCs on cancer cells are mediated through a secreted factor(s) which are enhanced by cancer cell-hMSC contact/communication and targeting both the ER and CXCR4 pathways is effective in decreasing the hMSC induction of MCF-7 cell proliferation and migration.
References
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Journal ArticleDOI
Multilineage Potential of Adult Human Mesenchymal Stem Cells
Mark F. Pittenger,Alastair Morgan Mackay,Stephen C. Beck,Rama K. Jaiswal,Robin Douglas,Joseph D. Mosca,Mark Aaron Moorman,Donald William Jr. Ward Road Simonetti,Stewart Craig,Daniel R. Marshak +9 more
TL;DR: Adult stem cells isolated from marrow aspirates of volunteer donors could be induced to differentiate exclusively into the adipocytic, chondrocytic, or osteocytic lineages.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues
TL;DR: Marrow stromal cells present an intriguing model for examining the differentiation of stem cells and have several characteristics that make them potentially useful for cell and gene therapy.
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Fibroblast growth factors
David M. Ornitz,Nobuyuki Itoh +1 more
TL;DR: A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems.
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Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
Edwin M. Horwitz,Darwin J. Prockop,Lorraine A. Fitzpatrick,Winston W.K. Koo,Patricia L. Gordon,Michael D. Neel,Michael D. Sussman,Paul J. Orchard,Jeffrey C. Marx,Reed E. Pyeritz,Malcolm K. Brenner +10 more
TL;DR: Improvements in total body bone mineral content and growth velocity were associated with increases in growth velocity and reduced frequencies of bone fracture, indicating the feasibility of allogeneic bone marrow transplantation in the treatment of osteogenesis imperfecta and perhaps other mesenchymal stem cell disorders as well.