Journal ArticleDOI
Broncho-alveolar macrophages express chemokines associated with leukocyte migration in a mouse model of asthma.
TLDR
Significant increases in WBCs, eosinophilia, mucus accumulation and goblet cell hyperplasia were observed in Ova sensitized and challenged mice, which correlated with increased expression of genes associated with alternatively activated M2 macrophages, supporting the notion that M2 BAMs play a role in eOSinophil and potentially other leukocyte migration patterns into asthmatic airways.About:
This article is published in Cellular Immunology.The article was published on 2013-02-01. It has received 32 citations till now. The article focuses on the topics: Eosinophil migration & Leukocyte migration.read more
Citations
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Journal ArticleDOI
Macrophage polarization and allergic asthma
TL;DR: Modulation of macrophage phenotypes through molecular intervention by targeting some of those potential macrophAGE regulators may have therapeutic potential in the treatment of allergic asthma and other allergic diseases.
Journal ArticleDOI
IL-10 enhances the phenotype of M2 macrophages induced by IL-4 and confers the ability to increase eosinophil migration.
TL;DR: In this paper, the effect of IL-4 and IL-10 in combination with macrophage subtype differentiation was investigated and it was shown that IL10 enhanced the M2 phenotype induced by IL4.
Journal ArticleDOI
IL-4/IL-13-Dependent and Independent Expression of miR-124 and Its Contribution to M2 Phenotype of Monocytic Cells in Normal Conditions and during Allergic Inflammation
Tatyana Veremeyko,Shafiuddin Siddiqui,Ilya Sotnikov,Amanda Yung,Eugene D. Ponomarev,Eugene D. Ponomarev +5 more
TL;DR: This study suggests that miR-124 serves as a regulator of the M2 polarization in various subsets of monocytic cells both in vitro and in vivo.
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Update on the role of alternatively activated macrophages in asthma.
Zhilong Jiang,Lei Zhu +1 more
TL;DR: Modulation of AM phenotypes through molecular intervention has therapeutic potential in the treatment of asthma and other allergic inflammatory diseases.
Journal ArticleDOI
Macrophages in Lung Injury, Repair, and Fibrosis
TL;DR: In this article, the authors summarized the current data on monocyte-derived macrophages that are recruited to the lung, as well as alveolar resident macrophage and their polarization, pyroptosis, and phagocytosis in acute lung injury (ALI).
References
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Journal ArticleDOI
Alternative activation of macrophages
TL;DR: The evidence in favour of alternative macrophage activation by the TH2-type cytokines interleukin-4 (IL-4) and IL-13 is assessed, and its limits and relevance to a range of immune and inflammatory conditions are defined.
Journal ArticleDOI
Monocyte and macrophage heterogeneity
Siamon Gordon,Philip R. Taylor +1 more
TL;DR: Recent studies have shown that monocyte heterogeneity is conserved in humans and mice, allowing dissection of its functional relevance: the different monocyte subsets seem to reflect developmental stages with distinct physiological roles, such as recruitment to inflammatory lesions or entry to normal tissues.
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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis.
John S. Munger,Xiaozhu Huang,Hisaaki Kawakatsu,Mark J. D. Griffiths,Stephen L. Dalton,Jianfeng Wu,Jean-Francois Pittet,Naftali Kaminski,Chrystelle Garat,Michael A. Matthay,Daniel B. Rifkin,Dean Sheppard +11 more
TL;DR: In this article, Latency-Aged Peptide (LAP) was shown to be a ligand for the integrin alpha v beta 6 and that alpha-v beta 6-expressing cells induce spatially restricted activation of TGF beta 1.
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The asthma epidemic.
TL;DR: Evidence of a plateau in the prevalence of asthma in many Western countries and the evidence of possible causal relations to factors such as air pollution, obesity, diet, and exposure to infections, antibiotics, and allergens is found.
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The development of allergic inflammation
TL;DR: It is important to understand the characteristics and consequences of acute and chronic allergic inflammation, and in particular to explore how mast cells can contribute to several features of this maladaptive pattern of immunological reaction.