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Open AccessJournal ArticleDOI

Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

Kamil Rodak, +2 more
- 02 Sep 2021 - 
- Vol. 13, Iss: 9, pp 3088
TLDR
In this paper, the authors present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson's disease, and others, not forgetting about the negative effects of excess caffeine.
Abstract
Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson’s disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.

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Citations
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Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?

TL;DR: The latest research about the potential effects of caffeine in neurodegenerative disorders prevention is summarized and the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time is discussed.
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The medicinal and aromatic plants as ingredients in functional beverage production

TL;DR: The functional beverages (FBs) market offers many opportunities for new product development with desirable and effective composition of nutrients and bioactive molecules (BAMs) aimed to deliver health benefits and improve human well-being as mentioned in this paper .
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Caffeine and Its Antioxidant Properties—It Is All about Dose and Source

TL;DR: In this article , a review of the effects of caffeine in modulating oxidative stress and assessing these benefits, considering the source and the dose administered, is presented, with the objective of assessing the benefits of the daily intake of caffeine from food or drink.
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Update to the Treatment of Parkinson’s Disease Based on the Gut-Brain Axis Mechanism

TL;DR: The research progress of the mechanism of the gut-brain axis (GBA) in PD is reviewed and the roles of α-synuclein, gut microbiota, immune inflammation, neuroendocrine, mitochondrial autophagy, and environmental toxins in the mechanism are discussed.
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The effect of caffeine on subsequent sleep: A systematic review and meta-analysis.

TL;DR: In this article , a systematic review and meta-analysis investigated the effect of caffeine on the characteristics of night-time sleep, with the intent to identify the time after which caffeine should not be consumed prior to bedtime.
References
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Journal ArticleDOI

Consumption of coffee associated with reduced risk of liver cancer: a meta-analysis

TL;DR: An inverse association between coffee consumption and liver cancer is suggested, because of the small number of studies, and further prospective studies are needed.
Journal ArticleDOI

The role of adenosine in Alzheimer's disease.

TL;DR: It is suggested that the adenosinergic system constitutes a new therapeutic target for AD, and caffeine and A2A receptor antagonists may have promise to manage cognitive dysfunction in AD.
Journal ArticleDOI

Does coffee protect against liver cirrhosis

TL;DR: The present study confirms, and further quantifies, the existence of an inverse association between coffee consumption and liver cirrhosis, and suggests the metabolism of caffeine is impaired in fasting subjects with liver Cirrhotic disease, and the association could be due to a reduction of coffee drinking in subjects with Liver Cirrhosis.
Journal ArticleDOI

Caffeine improves neuromuscular function during maximal dynamic exercise.

TL;DR: The concomitant improvement of mean fiber CV supports the hypothesis of an effect of caffeine on motor unit recruitment, and improves muscle performance during short‐duration maximal dynamic contractions.
Journal ArticleDOI

Caffeine as symptomatic treatment for Parkinson disease (Café-PD): A randomized trial

TL;DR: This study provides Class I evidence that for patients with PD, caffeine does not significantly improve motor manifestations, and Epidemiologic links between caffeine and lower PD risk do not appear to be explained by symptomatic effects.
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