Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?
Melania Ruggiero,Rosa Calvello,Chiara Porro,Giovanni Messina,Antonia Cianciulli,Maria Antonietta Panaro +5 more
TLDR
The latest research about the potential effects of caffeine in neurodegenerative disorders prevention is summarized and the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time is discussed.Abstract:
In recent years, there has been considerable research showing that coffee consumption seems to be beneficial to human health, as it contains a mixture of different bioactive compounds such as chlorogenic acids, caffeic acid, alkaloids, diterpenes and polyphenols. Neurodegenerative diseases (NDs) are debilitating, and non-curable diseases associated with impaired central, peripheral and muscle nervous systems. Several studies demonstrate that neuroinflammation mediated by glial cells—such as microglia and astrocytes—is a critical factor contributing to neurodegeneration that causes the dysfunction of brain homeostasis, resulting in a progressive loss of structure, function, and number of neuronal cells. This happens over time and leads to brain damage and physical impairment. The most known chronic NDs are represented by Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and Huntington’s disease (HD). According to epidemiological studies, regular coffee consumption is associated with a lower risk of neurodegenerative diseases. In this review, we summarize the latest research about the potential effects of caffeine in neurodegenerative disorders prevention and discuss the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time.read more
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Caffeine for Prevention of Alzheimer’s Disease: Is the A2A Adenosine Receptor Its Target?
Stefania Merighi,Alessia Travagli,Manuela Nigro,Silvia Pasquini,Martina Cappello,Chiara Contri,Katia Varani,Fabrizio Vincenzi,Pier Andrea Borea,Stefania Gessi +9 more
TL;DR: In this paper , a review provides a summary of the scientific data supporting the critical role that A2ARs play in memory loss and cognitive decline, as well as the evidence supporting the protective benefits against neurodegeneration that may be attained by caffeine's antagonistic action on these receptors.
Journal ArticleDOI
A2AR antagonist treatment for multiple sclerosis: Current progress and future prospects
TL;DR: In this paper , the potential effect of Adenosine A2A receptor (A2AR) antagonists on EAE/MS in both the peripheral immune system (PIS) and the central nervous system (CNS).
Journal ArticleDOI
Metabolomic Footprint of Disrupted Energetics and Amino Acid Metabolism in Neurodegenerative Diseases: Perspectives for Early Diagnosis and Monitoring of Therapy
Patrycja Maszka,Magdalena Kwaśniak-Butowska,Dominik Cysewski,Jarosław Sławek,Ryszard T. Smolenski,M Tomczyk +5 more
TL;DR: In this article , the authors summarized the alterations in brain energy and amino acid metabolism in Alzheimer's disease, Parkinson's disease and Huntington's disease (HD) and proposed a group of selected metabolites related to disturbed energy or mitochondrial metabolism as potential indicators or predictors of disease.
Journal ArticleDOI
ALSUntangled #70: caffeine.
Jessica Oliver Hatch,Paul E. Barkhaus,Ben Barnes,Morgan Beauchamp,Michael Benatar,Tulio E. Bertorini,Robert Bowser,C. Bromberg,J. Mascias Cadavid,Gregory T. Carter,Jesse Crayle,Mazen M. Dimachkie,David L. Ennist,Eva L. Feldman,Timothy R Fullam,Terry Heiman-Patterson,Sartaj Jhooty,Todd Levine,Xiaoyan Li,Isaac Lund,Nicholas J. Maragakis,Christopher J McDermott,Gary L. Pattee,Kaitlyn Pierce,Dylan Ratner,Kimberlee Staats,Paul Wicks,Martina Wiedau,Richard Bedlack +28 more
TL;DR: In this article , the authors reviewed alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS) and found that low doses of caffeine are safe and inexpensive, higher doses can cause serious side effects.
Posted ContentDOI
Variability of caffeine metabolism by CYP1A2 polymorphism in different populations
TL;DR: In this article , the European Food and Safety Authority (EFSA) evaluated the worldwide consumption of coffee to verify the potential use and abuse of caffeine by the population, with the aim to identify potential adverse effects on the human health.
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Yujun Hou,Xiuli Dan,Mansi Babbar,Yong Wei,Steen G. Hasselbalch,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +7 more
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