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Open AccessJournal ArticleDOI

Caffeine as a Factor Influencing the Functioning of the Human Body—Friend or Foe?

Kamil Rodak, +2 more
- 02 Sep 2021 - 
- Vol. 13, Iss: 9, pp 3088
TLDR
In this paper, the authors present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson's disease, and others, not forgetting about the negative effects of excess caffeine.
Abstract
Nowadays, caffeine is one of the most commonly consumed substances, which presents in many plants and products. It has both positive and negative effects on the human body, and its activity concerns a variety of systems including the central nervous system, immune system, digestive system, respiratory system, urinary tract, etc. These effects are dependent on quantity, the type of product in which caffeine is contained, and also on the individual differences among people (sex, age, diet etc.). The main aim of this review was to collect, present, and analyze the available information including the latest discoveries on the impact of caffeine on human health and the functioning of human body systems, taking into account the role of caffeine in individual disease entities. We present both the positive and negative sides of caffeine consumption and the healing properties of this purine alkaloid in diseases such as asthma, Parkinson’s disease, and others, not forgetting about the negative effects of excess caffeine (e.g., in people with hypertension, children, adolescents, and the elderly). In summary, we can conclude, however, that caffeine has a multi-directional influence on various organs of the human body, and because of its anti-oxidative properties, it was, and still is, an interesting topic for research studies including those aimed at developing new therapeutic strategies.

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Citations
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Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?

TL;DR: The latest research about the potential effects of caffeine in neurodegenerative disorders prevention is summarized and the role of controlled caffeine delivery systems in maintaining high plasma caffeine concentrations for an extended time is discussed.
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The medicinal and aromatic plants as ingredients in functional beverage production

TL;DR: The functional beverages (FBs) market offers many opportunities for new product development with desirable and effective composition of nutrients and bioactive molecules (BAMs) aimed to deliver health benefits and improve human well-being as mentioned in this paper .
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Caffeine and Its Antioxidant Properties—It Is All about Dose and Source

TL;DR: In this article , a review of the effects of caffeine in modulating oxidative stress and assessing these benefits, considering the source and the dose administered, is presented, with the objective of assessing the benefits of the daily intake of caffeine from food or drink.
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Update to the Treatment of Parkinson’s Disease Based on the Gut-Brain Axis Mechanism

TL;DR: The research progress of the mechanism of the gut-brain axis (GBA) in PD is reviewed and the roles of α-synuclein, gut microbiota, immune inflammation, neuroendocrine, mitochondrial autophagy, and environmental toxins in the mechanism are discussed.
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The effect of caffeine on subsequent sleep: A systematic review and meta-analysis.

TL;DR: In this article , a systematic review and meta-analysis investigated the effect of caffeine on the characteristics of night-time sleep, with the intent to identify the time after which caffeine should not be consumed prior to bedtime.
References
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Journal ArticleDOI

Effects of caffeine on plasma renin activity, catecholamines and blood pressure.

TL;DR: Under the conditions of study caffeine was a potent stimulator of plasma renin activity and adrenomedullary secretion and whether habitual ingestion has similar effects remains to be determined.
Journal ArticleDOI

Adenosine in the central nervous system: release mechanisms and extracellular concentrations.

TL;DR: Key characteristics of adenosine release in the brain in response to different stimuli will be summarized, and studies performed to evaluateadenosine concentrations under physiological and hypoxic/ischemic conditions will be described to evaluate the degree of adenoine receptor activation.
Journal ArticleDOI

Health Effects of Energy Drinks on Children, Adolescents, and Young Adults

TL;DR: Energy drinks have no therapeutic benefit, and many ingredients are understudied and not regulated, and concerns for potentially serious adverse effects in association with energy drink use are raised.
Journal ArticleDOI

Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease

TL;DR: The findings indicate that higher coffee and caffeine intake is associated with a significantly lower incidence of PD, and this effect appears to be independent of smoking.
Journal ArticleDOI

Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine

TL;DR: The A/A genotype may either be a direct cause of increased CYP1A2 activity, or be genetically linked to polymorphisms conferring high inducibility, and further studies are needed to define the role of this polymorphism on the pharmacokinetics of drugs metabolised by CYP 1A2 and in the activation of carcinogens.
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