Journal ArticleDOI
Cancer: a missing link in ecosystem functioning?
Marion Vittecoq,Benjamin Roche,Simon P. Daoust,Hugo Ducasse,Dorothée Missé,Jérôme Abadie,Sophie Labrut,François Renaud,Michel Gauthier-Clerc,Frédéric Thomas +9 more
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TLDR
The diversity of ways in which oncogenic phenomena, from precancerous lesions to generalized metastatic cancers, may affect ecological processes that govern biotic interactions are described.Abstract:
Cancer is a disease that affects the majority of metazoan species and, before directly causing host death, is likely to influence the competitive abilities of individuals, their susceptibility to pathogens, their vulnerability to predators, and their ability to disperse. Despite the potential importance of these ecological impacts, cancer is rarely incorporated into model ecosystems. We describe here the diversity of ways in which oncogenic phenomena, from precancerous lesions to generalized metastatic cancers, may affect ecological processes that govern biotic interactions. We argue that oncogenic phenomena, despite their complexity, can have significant and sometimes predictable ecological consequences. Our aim is to provide a new perspective on the ecological and evolutionary significance of cancer in wildlife, and to stimulate research on this topic.read more
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Journal ArticleDOI
Cancer across the tree of life: cooperation and cheating in multicellularity
C. Athena Aktipis,Amy M. Boddy,Gunther Jansen,Urszula Hibner,Michael E. Hochberg,Carlo C. Maley,Gerald S. Wilkinson +6 more
TL;DR: Understanding cancer as a breakdown of multicellular cooperation provides novel insights into cancer hallmarks and suggests a set of assays and biomarkers that can be applied across species and characterize the fundamental requirements for generating a cancer.
Journal ArticleDOI
The role of telomeres in the mechanisms and evolution of life-history trade-offs and ageing
TL;DR: Alternative hypotheses for the role of telomeres are evaluated, the potential for telomere biology to clarify the constraints at play in life-history evolution, and to explain the form of the current–future trade-offs and ageing trajectories that the authors observe today is considered.
Book ChapterDOI
Cancer Prevalence and Etiology in Wild and Captive Animals
Thomas Madsen,Audrey Arnal,Marion Vittecoq,Florence Bernex,Jérôme Abadie,Sophie Labrut,Deborah Garcia,Dominique Faugere,Karin Lemberger,Christa Beckmann,Benjamin Roche,Frédéric Thomas,Beata Ujvari +12 more
TL;DR: This chapter focuses on cancer in wild vertebrates and provides a comprehensive and an updated list of cancer prevalence and etiology in the wild, as well as in captive animals.
Journal ArticleDOI
A framework for how environment contributes to cancer risk
TL;DR: It is argued that anthropogenic influences, in particular, explain much of the present-day cancer risk across life, including in humans, and combined risks of all cancers in a population beyond c.
Journal ArticleDOI
The evolutionary ecology of transmissible cancers
TL;DR: This work defines four conditions that are necessary and sufficient for direct passage of cancer cells between either vertebrate or invertebrate hosts and provides novel insights into the dynamics that both promote and constrain their growth.
References
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Journal ArticleDOI
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Journal ArticleDOI
Population biology of infectious diseases: Part II
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