Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium
Li Rita Zhang,Hal Morgenstern,Sander Greenland,Shen Chih Chang,Philip Lazarus,M. Dawn Teare,Penella J. Woll,Irene Orlow,Brian Cox,Yonathan Brhane,Geoffrey Liu,Rayjean J. Hung +11 more
TLDR
Results from the pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long‐term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.Abstract:
To investigate the association between cannabis smoking and lung cancer risk, data on 2,159 lung cancer cases and 2,985 controls were pooled from 6 case-control studies in the US, Canada, UK, and New Zealand within the International Lung Cancer Consortium. Study-specific associations between cannabis smoking and lung cancer were estimated using unconditional logistic regression adjusting for sociodemographic factors, tobacco smoking status and pack-years; odds-ratio estimates were pooled using random effects models. Subgroup analyses were done for sex, histology and tobacco smoking status. The shapes of dose-response associations were examined using restricted cubic spline regression. The overall pooled OR for habitual versus nonhabitual or never users was 0.96 (95% CI: 0.66-1.38). Compared to nonhabitual or never users, the summary OR was 0.88 (95%CI: 0.63-1.24) for individuals who smoked 1 or more joint-equivalents of cannabis per day and 0.94 (95%CI: 0.67-1.32) for those consumed at least 10 joint-years. For adenocarcinoma cases the ORs were 1.73 (95%CI: 0.75-4.00) and 1.74 (95%CI: 0.85-3.55), respectively. However, no association was found for the squamous cell carcinoma based on small numbers. Weak associations between cannabis smoking and lung cancer were observed in never tobacco smokers. Spline modeling indicated a weak positive monotonic association between cumulative cannabis use and lung cancer, but precision was low at high exposure levels. Results from our pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long-term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.read more
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Safety Considerations in Cannabinoid-Based Medicine.
Sven Gottschling,Oyedeji Ayonrinde,Arun Bhaskar,Marc Blockman,Oscar D'Agnone,Danial Schecter,Luis David Suárez Rodríguez,Sherry Yafai,Claude Cyr +8 more
TL;DR: Across diverse indications, dizziness and fatigue are generally the most common adverse events experienced by patients receiving THC or combined THC and CBD, and the recommended route of administration is oral ingestion, as smoking medicinal cannabinoid products potentially releases mutagenic and carcinogenic by-products.
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Lung Cancer: Epidemiology and Screening.
TL;DR: In this article , risk factor modification and screening are critical to improving survival in patients with lung cancer, identifying at-risk populations for access to care and screening programs will improve overall outcomes.
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Marijuana and the lung: hysteria or cause for concern?
Luis Ribeiro,Philip W. Ind +1 more
TL;DR: Cannabis smoking has increased and is likely to increase further with relaxation of legalisation and medicinal use of cannabinoids, and the mechanism behind this is unclear; however, given the increasing prevalence and legalisation it is important to keep in mind the differences in clinical practice.
Journal ArticleDOI
Medicinal Cannabis in Orthopaedic Practice.
TL;DR: Given the current paucity of evidence in the orthopaedic cohort, future research is warranted in this area to determine the efficacy and safety before endorsements can be made by orthopedic surgeons.
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Illicit Cannabis Usage as a Management Strategy in New Zealand Women with Endometriosis: An Online Survey
Mike Armour,Mike Armour,Justin Sinclair,Geoffrey Noller,Jane E. Girling,Maria Larcombe,Mahmoud A Al-Dabbas,Erika Hollow,Deborah Bush,Neil P. Johnson,Neil P. Johnson +10 more
TL;DR: Cannabis is reported as an effective intervention for pain and other endometriosis symptoms with potential substitution effects on opioid usage.
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