Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium
Li Rita Zhang,Hal Morgenstern,Sander Greenland,Shen Chih Chang,Philip Lazarus,M. Dawn Teare,Penella J. Woll,Irene Orlow,Brian Cox,Yonathan Brhane,Geoffrey Liu,Rayjean J. Hung +11 more
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TLDR
Results from the pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long‐term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.Abstract:
To investigate the association between cannabis smoking and lung cancer risk, data on 2,159 lung cancer cases and 2,985 controls were pooled from 6 case-control studies in the US, Canada, UK, and New Zealand within the International Lung Cancer Consortium. Study-specific associations between cannabis smoking and lung cancer were estimated using unconditional logistic regression adjusting for sociodemographic factors, tobacco smoking status and pack-years; odds-ratio estimates were pooled using random effects models. Subgroup analyses were done for sex, histology and tobacco smoking status. The shapes of dose-response associations were examined using restricted cubic spline regression. The overall pooled OR for habitual versus nonhabitual or never users was 0.96 (95% CI: 0.66-1.38). Compared to nonhabitual or never users, the summary OR was 0.88 (95%CI: 0.63-1.24) for individuals who smoked 1 or more joint-equivalents of cannabis per day and 0.94 (95%CI: 0.67-1.32) for those consumed at least 10 joint-years. For adenocarcinoma cases the ORs were 1.73 (95%CI: 0.75-4.00) and 1.74 (95%CI: 0.85-3.55), respectively. However, no association was found for the squamous cell carcinoma based on small numbers. Weak associations between cannabis smoking and lung cancer were observed in never tobacco smokers. Spline modeling indicated a weak positive monotonic association between cumulative cannabis use and lung cancer, but precision was low at high exposure levels. Results from our pooled analyses provide little evidence for an increased risk of lung cancer among habitual or long-term cannabis smokers, although the possibility of potential adverse effect for heavy consumption cannot be excluded.read more
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References
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Tracheobronchial Changes in Habitual, Heavy Smokers of Marijuana With and Without Tobacco
TL;DR: In this paper, the authors performed flexible fiberoptic bronchoscopy in 29 habitual, heavy marijuana smokers 25 to 45 years of age, with and without concomitant tobacco smoking, to inspect and biopsy their proximal tracheobronchial tree for the evaluation of histopathologic changes Control tobacco smokers (TS) and nonsmokers (NS) residing in the same metropolitan area were similarly studied and compared with the marijuana smokers (MS) and marijuana-tobacco smokers (MTS)
Journal ArticleDOI
International Lung Cancer Consortium: Pooled Analysis of Sequence Variants in DNA Repair and Cell Cycle Pathways
Rayjean Hung,Rayjean Hung,David C. Christiani,Angela Risch,Odilia Popanda,Aage Haugen,Shan Zienolddiny,Simone Benhamou,Simone Benhamou,Christine Bouchardy,Qing Lan,Margaret R. Spitz,H.-Erich Wichmann,Loic LeMarchand,Paolo Vineis,Giuseppe Matullo,Chikako Kiyohara,Zuo-Feng Zhang,Benhnaz Pezeshki,Curtis C. Harris,Leah E. Mechanic,Adeline Seow,Daniel P.K. Ng,Neonila Szeszenia-Dabrowska,David Zaridze,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Lenka Foretova,Vladimir Janout,Vladimir Bencko,Neil E. Caporaso,Chu Chen,Eric J. Duell,Gary E. Goodman,John K. Field,Richard S. Houlston,Yun Chul Hong,Maria Teresa Landi,Philip Lazarus,Joshua E. Muscat,John R. McLaughlin,Ann G. Schwartz,Hongbing Shen,Isabelle Stücker,Kazuo Tajima,Keitaro Matsuo,Michael J. Thun,Ping Yang,John K. Wiencke,Angeline S. Andrew,Stéphanie Monnier,Paolo Boffetta,Paul Brennan +54 more
TL;DR: A pooled analysis of genetic variants in DNA repair pathways found four variants to be weakly associated with lung cancer risk with borderline significance and future priorities of International Lung Cancer Consortium include coordinated genotyping and multistage validation for ongoing genome-wide association studies.
Journal ArticleDOI
Cannabis smoking and risk of lung cancer in men: a pooled analysis of three studies in Maghreb.
Julien Berthiller,Kurt Straif,Mathieu Boniol,Nicolas Voirin,Veronique Benhaim-Luzon,Wided Ben Ayoub,Iman Dari,Slimane Laouamri,M. Hamdi-Cherif,Mohamed Bartal,Fahrat Ben Ayed,Annie J. Sasco +11 more
TL;DR: The results suggest that cannabis smoking may be a risk factor for lung cancer, however, residual confounding by tobacco smoking or other potential confounders may explain part of the increased risk.
Journal ArticleDOI
The UDP-Glucuronosyltransferase 2B17 Gene Deletion Polymorphism: Sex-Specific Association with Urinary 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol Glucuronidation Phenotype and Risk for Lung Cancer
Carla J. Gallagher,Joshua E. Muscat,Amy N. Hicks,Yan Zheng,Anne Marie Dyer,Gary A. Chase,John P. Richie,Philip Lazarus +7 more
TL;DR: The association of the UGT2B17 deletion with increased lung adenocarcinoma in women is consistent with its association with decreased NNAL glucuronidation rates in women and with studies showing that NNal is a selective inducer of lung adanoma in experimental animals.
Journal ArticleDOI
A case-control study of lung cancer in Casablanca, Morocco.
Annie J. Sasco,Annie J. Sasco,Ray M. Merrill,Ray M. Merrill,Imane Dari,Veronique Benhaim-Luzon,Florence Carriot,Cristina I. Cann,Cristina I. Cann,Mohamed Bartal +9 more
TL;DR: This study confirms known risk factors for lung cancer and uncovers potential new etiologic ones such as the role of hashish/kiff, which were confirmed in a hospital-based case–control study in Casablanca, Morocco.