Journal ArticleDOI
Carotenoids, inflammation, and oxidative stress—implications of cellular signaling pathways and relation to chronic disease prevention
Anouk Kaulmann,Torsten Bohn +1 more
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TLDR
Current knowledge on carotenoids and metabolites with respect to their ability to modulate inflammatory and oxidative stress pathways are summarized and potential dose-health relations are discussed.About:
This article is published in Nutrition Research.The article was published on 2014-11-01. It has received 474 citations till now. The article focuses on the topics: KEAP1 & Carotenoid.read more
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Nrf2 signaling pathway: Pivotal roles in inflammation.
TL;DR: The members of the Keap1/Nrf2/ARE signal pathway and its downstream genes, the effects of this pathway on animal models of inflammatory diseases, and crosstalk with the NF-κB pathway are discussed.
Journal ArticleDOI
A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health
Manuel Rodríguez-Concepción,Javier Avalos,M. Luisa Bonet,Albert Boronat,Lourdes Gómez-Gómez,Dámaso Hornero-Méndez,M. Carmen Limón,Antonio J. Meléndez-Martínez,Begoña Olmedilla-Alonso,Andreu Palou,Joan Ribot,María Jesús Rodrigo,Lorenzo Zacarías,Changfu Zhu +13 more
TL;DR: This review, contributed by scientists of complementary disciplines related to carotenoid research, covers recent advances and provides a perspective on future directions on the subjects of carotENoid metabolism, biotechnology, and nutritional and health benefits.
Journal ArticleDOI
Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis.
Mohammed Iddir,Alex Brito,Giulia Dingeo,Sofia Sosa Fernandez Del Campo,Hanen Samouda,Michael R. La Frano,Torsten Bohn +6 more
TL;DR: The importance of an optimal status of relevant nutrients to effectively reduce inflammation and oxidative stress, thereby strengthening the immune system during the COVID-19 crisis is highlighted.
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Carotenoids: biochemistry, pharmacology and treatment
TL;DR: The biological and immunological activities of the main carotenoids used for the treatment of various diseases and their possible mechanisms of action are described.
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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
TL;DR: The relationship between Nrf2 signaling and the inflammation as well as possible approaches for the therapeutic modulation of this pathway are examined.
References
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Dose translation from animal to human studies revisited
TL;DR: BSA correlates well across several mammalian species with several parameters of biology, including oxygen utilization, caloric expenditure, basal metabolism, blood volume, circulating plasma proteins, and renal function, and is advocated as a factor when converting a dose for translation from animals to humans.
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Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases
Gary L. Johnson,Razvan Lapadat +1 more
TL;DR: Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes, and inhibitors of these enzymes are being explored as anticancer agents.
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Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
TL;DR: Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Journal ArticleDOI
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
TL;DR: Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
Journal ArticleDOI
NF-κB: a key role in inflammatory diseases
Paul P. Tak,Gary S. Firestein +1 more
TL;DR: The specificity of various NF-κB proteins, their role in inflammatory disease, the regulation of NF-β proteins and IκB activity by IκBs and IkkB kinase, and the development of therapeutic strategies aimed at inhibition are discussed.
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