Q1. What are the contributions in "Catechol-o-methlytransferase inhibition alters pain and anxiety- related volitional behaviors through activation of β-adrenergic receptors in the rat" ?
In order to more closely mimic the characteristics of human chronic pain conditions associated with prolonged reductions in COMT, the present study sought to determine volitional pain-related and anxiety-like behavioral responses following sustained as well as acute COMT inhibition using an operant 10–45°C thermal place preference task and a light/dark preference test. Collectively, these findings provide the first evidence that stimulation of ARs following acute or chronic COMT inhibition drives cognitive-affective behaviors associated with heightened pain that affects multiple body sites. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to their customers the authors are providing this early version of the manuscript. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Further, sustained administration of OR486 increased anxiety behavior in response to bright light, as well as abdominal mechanosensation.