Journal ArticleDOI
Causes and consequences of micronuclei.
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TLDR
In this paper, the authors discuss how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronuclearation, with a focus on the effects of DNA degradation.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2021-06-01. It has received 60 citations till now. The article focuses on the topics: Chromothripsis & DNA repair.read more
Citations
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Blocking Genomic Instability Prevents Acquired Resistance to MAPK Inhibitor Therapy in Melanoma
TL;DR: In this paper , after MAPK inhibitor (MAPKi) therapy in patients and mice bearing patient-derived xenografts (PDX), acquired resistant genomes of metastatic cutaneous melanoma specifically amplify resistance-driver, nonhomologous end-joining (NHEJ), and homologous recombination repair (HRR) genes via complex genomic rearrangements (CGR) and extrachromosomal DNAs (ecDNA).
Journal ArticleDOI
A kinesin‐based approach for inducing chromosome‐specific mis‐segregation in human cells
My Anh Truong,Paula Cané-Gasull,Sippe G. de Vries,Wilco Nijenhuis,René Wardenaar,Lukas C. Kapitein,Floris Foijer,Susanne M.A. Lens +7 more
TL;DR: In this article , a microtubule minus-end-directed kinesin (Kinesin14VIb) from Physcomitrella patens was used to induce mis-segregation of specific chromosomes in different human cell types.
Posted ContentDOI
Telomeric 8-Oxoguanine Drives Rapid Premature Senescence In The Absence Of Telomere Shortening
Ryan P. Barnes,de Rosa M,Thosar Sa,Ariana C. Detwiler,Roginskaya,Van Houten B,Marcel P. Bruchez,Jacob Stewart-Ornstein,Patricia L. Opresko +8 more
TL;DR: In this article, the authors proposed that oxidative stress promotes rapid senescence by producing oxidative base lesions which drive replication-dependent telomere fragility and dysfunction in the absence of shortening and shelterin loss.
Journal ArticleDOI
Preventing excess replication origin activation to ensure genome stability
TL;DR: In this article , the authors review molecular pathways that modulate replication origin dormancy, prevent excess origin activation, and detect, encapsulate, and eliminate persistent excess DNA in cancer cells.
Journal ArticleDOI
Preventing excess replication origin activation to ensure genome stability.
TL;DR: In this paper, the authors review molecular pathways that modulate replication origin dormancy, prevent excess origin activation, and detect, encapsulate, and eliminate persistent excess DNA in cancer cells.
References
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Journal ArticleDOI
Cellular senescence: when bad things happen to good cells
TL;DR: Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
Journal ArticleDOI
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Philip J. Stephens,Christopher Greenman,Beiyuan Fu,Fengtang Yang,Graham R. Bignell,Laura Mudie,Erin Pleasance,King Wai Lau,David Beare,Lucy Stebbings,Stuart McLaren,Meng-Lay Lin,David J. McBride,Ignacio Varela,Serena Nik-Zainal,Catherine Leroy,Mingming Jia,Andrew Menzies,Adam Butler,Jon W. Teague,Michael A. Quail,John Burton,Harold Swerdlow,Nigel P. Carter,Laura Morsberger,Christine A. Iacobuzio-Donahue,George A. Follows,Anthony R. Green,Adrienne M. Flanagan,Adrienne M. Flanagan,Michael R. Stratton,P. Andrew Futreal,Peter J. Campbell,Peter J. Campbell +33 more
TL;DR: It is found that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis, which has important implications for the origins of genomic remodeling and temporal emergence of cancer.
Journal ArticleDOI
Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
TL;DR: Recent advances in understanding of the cGAS–STING pathway are reviewed, focusing on the regulatory mechanisms and roles of this pathway in heath and disease.
Journal ArticleDOI
DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta,Neil J. Ganem,Neil J. Ganem,Regina Dagher,Regina Dagher,Alexandra B. Lantermann,Elena Ivanova,Yunfeng Pan,Luigi Nezi,Alexei Protopopov,Dipanjan Chowdhury,David Pellman,David Pellman +12 more
TL;DR: A mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei is identified, which potentially lead to mutations and chromosome rearrangements that can integrate into the genome.
Journal ArticleDOI
Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
Michael Fenech,Micheline Kirsch-Volders,Adayapalam T. Natarajan,Jordi Surrallés,J. W. Crott,James M. Parry,Hannu Norppa,David A. Eastmond,James D. Tucker,Philip Thomas +9 more
TL;DR: The wealth of knowledge currently available that best explains the formation of these important nuclear anomalies that are commonly seen in cancer and are indicative of genome damage events that could increase the risk of developmental and degenerative diseases are summarized.