Journal ArticleDOI
Causes and consequences of micronuclei.
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TLDR
In this paper, the authors discuss how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronuclearation, with a focus on the effects of DNA degradation.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2021-06-01. It has received 60 citations till now. The article focuses on the topics: Chromothripsis & DNA repair.read more
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DNA damage and repair in age-related inflammation
TL;DR: In this article , the authors discuss the mechanisms by which DNA damage induces inflammation, such as through activation of the cGAS-STING axis and NF-κB activation by ATM.
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Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities
TL;DR: An overview of several nuclear abnormalities, including micronuclei, nuclear envelope invaginations, blebs and ruptures, and current methods used for image-based quantification of these abnormalities are reviewed, and several parameters that can be used to quantify nuclear shape are discussed.
Journal ArticleDOI
Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening
TL;DR: In this paper , the authors proposed that oxidative stress promotes rapid senescence by producing oxidative base lesions that drive replication-dependent telomere fragility and dysfunction in the absence of shortening and shelterin loss.
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Principles and functions of pericentromeric satellite DNA clustering into chromocenters.
TL;DR: In this article , a review of the literature on pericentromeric satellite DNA and its organization and functions across eukaryotic species is presented, focusing on chromocenters.
Journal ArticleDOI
Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse
Aladin Haimovici,Christoph Höfer,Mohamed Tarek Badr,Elham Bavafaye Haghighi,Tarek Amer,Melanie Boerries,Peter Bronsert,Ievgen Glavynskyi,Deborah Fanfone,Gabriel Ichim,Nico Thilmany,Arnim Weber,Tilman Brummer,Corinna Spohr,Rupert Öllinger,Klaus-Peter Janssen,Roland Rad,Georg Häcker +17 more
TL;DR: In this article , the authors tested whether spontaneously appearing micronuclei in cancer cells are linked to sub-lethal apoptotic signals and found that low-level activity in the mitochondrial apoptosis apparatus operates through CAD-dependent gene induction and STING-activation and has substantial impact on metastasis in cancer patients.
References
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Journal ArticleDOI
Repair of nuclear ruptures requires barrier-to-autointegration factor
Charles T Halfmann,Rhiannon M. Sears,Aditya Katiyar,Brook W. Busselman,London K. Aman,Qiao Zhang,Christopher S. O’Bryan,Thomas E. Angelini,Tanmay P. Lele,Kyle J. Roux +9 more
TL;DR: A role for the protein BAF is described in nuclear envelope rupture repair, yet surprisingly, ESCRT-III is not required to repair ruptures.
Journal ArticleDOI
BAF restricts cGAS on nuclear DNA to prevent innate immune activation.
Baptiste Guey,Marilena Wischnewski,Alexiane Decout,Kristina Makasheva,Murat Kaynak,Mahmut Selman Sakar,Beat Fierz,Andrea Ablasser +7 more
TL;DR: The observations reveal a safeguard mechanism, distinct from physical separation, by which cells protect themselves against aberrant immune responses toward genomic DNA, which suggests that the regulation of DNA detection by the innate immune system relies on more complex mechanisms than simple physical separation alone.
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APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.
John Maciejowski,John Maciejowski,Aikaterini Chatzipli,Alexandra Dananberg,Kevan Chu,Eleonore Toufektchan,Leszek J. Klimczak,Dmitry A. Gordenin,Peter J. Campbell,Titia de Lange +9 more
TL;DR: It is shown that the cytoplasmic exonuclease TREX1, which promotes the resolution of dicentric chromosomes 4 , plays a prominent role in chromothriptic fragmentation and the kataegis observed at chromothripsis breakpoints is the consequence of cytosine deamination by APOBEC3B.
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Chromosome Pulverization in Human Cells With Micronuclei
Hatao Kato,Avery A. Sandberg +1 more
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BRCA2 deficiency instigates cGAS-mediated inflammatory signaling and confers sensitivity to tumor necrosis factor-alpha-mediated cytotoxicity
Anne Margriet Heijink,Francien Talens,Lucas T. Jae,Stephanie E van Gijn,Rudolf S N Fehrmann,Thijn R. Brummelkamp,Thijn R. Brummelkamp,Marcel A. T. M. van Vugt +7 more
TL;DR: Using a genome-wide genetic screen in near-haploid KBM-7 cells, it is shown that tumor necrosis factor-alpha (TNFα) signaling is a determinant of cell survival upon BRCA2 inactivation.