Journal ArticleDOI
Causes and consequences of micronuclei.
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TLDR
In this paper, the authors discuss how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronuclearation, with a focus on the effects of DNA degradation.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2021-06-01. It has received 60 citations till now. The article focuses on the topics: Chromothripsis & DNA repair.read more
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Cancer Genomic Rearrangements and Copy Number Alterations from Errors in Cell Division
TL;DR: In this paper , the authors summarize the progress and survey the major unresolved questions, with particular emphasis on the relative contributions of chromosome fragmentation and DNA replication errors to complex chromosomal alterations.
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The Contribution of Lysosomes to DNA Replication.
TL;DR: In this article, the interplay between lysosomal function and DNA replication through nucleic acid degradation and nucleotide biosynthesis is discussed, and how these could be exploited for therapeutic purposes.
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HIV Infection, Chromosome Instability, and Micronucleus Formation
TL;DR: In this paper , the authors reviewed studies that have evaluated genomic instability using micronucleus assays in the context of HIV infection and discussed the connections between HIV infection, immunosenescence and age-related disease.
Journal ArticleDOI
Processing DNA lesions during mitosis to prevent genomic instability
H. Rudolf de Boer,Soh Nishimoto +1 more
TL;DR: In this article , the authors provide an overview of how mitotic cells process lesions that escape checkpoint surveillance, with a focus on joint DNA molecules arising from under-replication and persistent recombination intermediates, as well as DNA catenanes.
Journal ArticleDOI
Active genetics comes alive
Valentino M. Gantz,Ethan Bier +1 more
TL;DR: The substantial advances that have been made on all of these fronts are summarized and the next phase of this rapidly expanding and impactful field is looked forward to.
References
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Journal ArticleDOI
Cellular senescence: when bad things happen to good cells
TL;DR: Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.
Journal ArticleDOI
Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development
Philip J. Stephens,Christopher Greenman,Beiyuan Fu,Fengtang Yang,Graham R. Bignell,Laura Mudie,Erin Pleasance,King Wai Lau,David Beare,Lucy Stebbings,Stuart McLaren,Meng-Lay Lin,David J. McBride,Ignacio Varela,Serena Nik-Zainal,Catherine Leroy,Mingming Jia,Andrew Menzies,Adam Butler,Jon W. Teague,Michael A. Quail,John Burton,Harold Swerdlow,Nigel P. Carter,Laura Morsberger,Christine A. Iacobuzio-Donahue,George A. Follows,Anthony R. Green,Adrienne M. Flanagan,Adrienne M. Flanagan,Michael R. Stratton,P. Andrew Futreal,Peter J. Campbell,Peter J. Campbell +33 more
TL;DR: It is found that one, or indeed more than one, cancer-causing lesion can emerge out of the genomic crisis, which has important implications for the origins of genomic remodeling and temporal emergence of cancer.
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Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing
TL;DR: Recent advances in understanding of the cGAS–STING pathway are reviewed, focusing on the regulatory mechanisms and roles of this pathway in heath and disease.
Journal ArticleDOI
DNA breaks and chromosome pulverization from errors in mitosis
Karen Crasta,Neil J. Ganem,Neil J. Ganem,Regina Dagher,Regina Dagher,Alexandra B. Lantermann,Elena Ivanova,Yunfeng Pan,Luigi Nezi,Alexei Protopopov,Dipanjan Chowdhury,David Pellman,David Pellman +12 more
TL;DR: A mechanism by which errors in mitotic chromosome segregation generate DNA breaks via the formation of structures called micronuclei is identified, which potentially lead to mutations and chromosome rearrangements that can integrate into the genome.
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Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells
Michael Fenech,Micheline Kirsch-Volders,Adayapalam T. Natarajan,Jordi Surrallés,J. W. Crott,James M. Parry,Hannu Norppa,David A. Eastmond,James D. Tucker,Philip Thomas +9 more
TL;DR: The wealth of knowledge currently available that best explains the formation of these important nuclear anomalies that are commonly seen in cancer and are indicative of genome damage events that could increase the risk of developmental and degenerative diseases are summarized.