Journal ArticleDOI
Causes and consequences of micronuclei.
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TLDR
In this paper, the authors discuss how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronuclearation, with a focus on the effects of DNA degradation.About:
This article is published in Current Opinion in Cell Biology.The article was published on 2021-06-01. It has received 60 citations till now. The article focuses on the topics: Chromothripsis & DNA repair.read more
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DNA damage and repair in age-related inflammation
TL;DR: In this article , the authors discuss the mechanisms by which DNA damage induces inflammation, such as through activation of the cGAS-STING axis and NF-κB activation by ATM.
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Current Methods and Pipelines for Image-Based Quantitation of Nuclear Shape and Nuclear Envelope Abnormalities
TL;DR: An overview of several nuclear abnormalities, including micronuclei, nuclear envelope invaginations, blebs and ruptures, and current methods used for image-based quantification of these abnormalities are reviewed, and several parameters that can be used to quantify nuclear shape are discussed.
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Telomeric 8-oxo-guanine drives rapid premature senescence in the absence of telomere shortening
TL;DR: In this paper , the authors proposed that oxidative stress promotes rapid senescence by producing oxidative base lesions that drive replication-dependent telomere fragility and dysfunction in the absence of shortening and shelterin loss.
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Principles and functions of pericentromeric satellite DNA clustering into chromocenters.
TL;DR: In this article , a review of the literature on pericentromeric satellite DNA and its organization and functions across eukaryotic species is presented, focusing on chromocenters.
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Spontaneous activity of the mitochondrial apoptosis pathway drives chromosomal defects, the appearance of micronuclei and cancer metastasis through the Caspase-Activated DNAse
Aladin Haimovici,Christoph Höfer,Mohamed Tarek Badr,Elham Bavafaye Haghighi,Tarek Amer,Melanie Boerries,Peter Bronsert,Ievgen Glavynskyi,Deborah Fanfone,Gabriel Ichim,Nico Thilmany,Arnim Weber,Tilman Brummer,Corinna Spohr,Rupert Öllinger,Klaus-Peter Janssen,Roland Rad,Georg Häcker +17 more
TL;DR: In this article , the authors tested whether spontaneously appearing micronuclei in cancer cells are linked to sub-lethal apoptotic signals and found that low-level activity in the mitochondrial apoptosis apparatus operates through CAD-dependent gene induction and STING-activation and has substantial impact on metastasis in cancer patients.
References
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Journal ArticleDOI
Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence
Selene Glück,Baptiste Guey,Muhammet F. Gulen,Katharina Wolter,Tae-Won Kang,Tae-Won Kang,Niklas Arndt Schmacke,Anne Bridgeman,Jan Rehwinkel,Lars Zender,Lars Zender,Andrea Ablasser +11 more
TL;DR: A role for innate DNA sensing in the regulation of senescence and the SASP is defined and it is found that cyclic GMP-AMP synthase (cGAS) recognizes cytosolic chromatin fragments in senescent cells.
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cGAS is essential for cellular senescence
TL;DR: It is shown that cGAS mediates cellular senescence and retards immortalization, a cytosolic DNA sensor that activates innate immunity, which is distinct from, and complementary to, the role ofcGAS in activating antitumor immunity.
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Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei
TL;DR: This study shows that NE collapse is a key event underlying MN dysfunction and establishes a link between aberrant NE organization and aneuploidy, suggesting that disrupted MN could be a useful objective biomarker for genomic instability in solid tumors.
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Chromothripsis and Kataegis Induced by Telomere Crisis.
TL;DR: It is proposed that chromothripsis in human cancer may arise through TREX1-mediated fragmentation of dicentric chromosomes formed in telomere crisis through the generation of the ssDNA and the resolution of the chromatin bridges.
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Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
TL;DR: It is reported that Trex1, ordinarily associated with the endoplasmic reticulum (ER), relocalizes to the S phase nucleus after gamma irradiation or hydroxyurea treatment and acts on a single-stranded DNA polynucleotide species generated from processing of aberrant replication intermediates to attenuate DNA damage checkpoint signaling and prevent pathological immune activation.